Radon inhalation suppresses nephropathy in streptozotocin-induced type-1 diabetic mice

Yuichi Nishiyama, Takahiro Kataoka, Keiko Yamato, Reo Etani, Takehito Taguchi, Kiyonori Yamaoka

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2 Citations (Scopus)

Abstract

In this study, we investigated the suppressive effects of radon inhalation against nephropathy in C57BL/6J mice with type-1 diabetes induced by intraperitoneal injection of streptozotocin (50 mg/kg weight, given five times). Four weeks after diabetes induction, the diabetic mice were continuously treated with inhaled radon-222 of 2000 Bq/m3 or air only (sham) for four weeks. The results showed that radon inhalation did not affect type-1 diabetic symptoms such as body weight loss, hyperglycemia, and hypoinsulinemia. However, diabetic mice treated with radon showed lower urinary albumin excretion and fibrotic change in renal glomeruli compared with diabetic mice not treated with radon. Furthermore, renal superoxide dismutase activity and glutathione content were significantly higher in diabetic mice treated with radon than in diabetic mice not treated with radon. These findings suggested that radon inhalation enhanced renal antioxidants activities, resulting in the suppression of diabetic nephropathy. This study may contribute to the development of a novel approach in the treatment of nephropathy for diabetic patients.

Original languageEnglish
Pages (from-to)909-915
Number of pages7
Journaljournal of nuclear science and technology
Volume53
Issue number6
DOIs
Publication statusPublished - Jun 2 2016

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Keywords

  • antioxidant
  • diabetic nephropathy
  • oxidative stress
  • radon
  • reactive oxygen species

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Nuclear Energy and Engineering

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