Radon inhalation protects mice from carbon-tetrachloride-induced hepatic and renal damage

Takahiro Kataoka; Yuichi Nishiyama; Teruaki Toyota; Masaaki Yoshimoto; Akihiro Sakoda; Yuu Ishimori; Yutaka Aoyama; Takehito Taguchi; Kiyonori Yamaoka

doi:10.1007/s10753-010-9263-7

Radon inhalation protects mice from carbon-tetrachloride-induced hepatic and renal damage

Takahiro Kataoka, Yuichi Nishiyama, Teruaki Toyota, Masaaki Yoshimoto, Akihiro Sakoda, Yuu Ishimori, Yutaka Aoyama, Takehito Taguchi, Kiyonori Yamaoka

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

We assessed whether radon inhalation provided protection from carbon tetrachloride (CCl ₄)-induced hepatic and renal damage in mice. Mice were subjected to intraperitoneal injection of CCl ₄ after inhaling approximately 18 kBq/m ³ radon for 6 h. Radon inhalation significantly increased total glutathione (t-GSH) content and glutathione peroxidase (GPx) activity in the liver and kidney. Injection of CCl ₄ was associated with significantly higher levels of glutamic oxaloacetic transaminase (GOT) and alkaline phosphatase (ALP) activity and creatinine level in serum, and pretreatment with radon significantly decreased the GOT and ALP activity and creatinine level associated with CCl ₄ injection, suggesting that radon inhalation alleviates CCl ₄-induced hepatic and renal damage. The t-GSH contents and GPx activity in the liver and kidney of animals pretreated with radon were significantly higher than those of the CCl ₄-only group. These findings suggested that radon inhalation activated antioxidative functions and inhibited CCl ₄-induced hepatic and renal damage in mice.

Original language	English
Pages (from-to)	559-567
Number of pages	9
Journal	Inflammation
Volume	34
Issue number	6
DOIs	https://doi.org/10.1007/s10753-010-9263-7
Publication status	Published - Dec 2011

Keywords

antioxidative function
carbon tetrachloride
kidney
liver
radon inhalation

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1007/s10753-010-9263-7

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Radon inhalation protects mice from carbon-tetrachloride-induced hepatic and renal damage. / Kataoka, Takahiro; Nishiyama, Yuichi; Toyota, Teruaki; Yoshimoto, Masaaki; Sakoda, Akihiro; Ishimori, Yuu; Aoyama, Yutaka; Taguchi, Takehito; Yamaoka, Kiyonori.

In: Inflammation, Vol. 34, No. 6, 12.2011, p. 559-567.

Research output: Contribution to journal › Article › peer-review

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abstract = "We assessed whether radon inhalation provided protection from carbon tetrachloride (CCl 4)-induced hepatic and renal damage in mice. Mice were subjected to intraperitoneal injection of CCl 4 after inhaling approximately 18 kBq/m 3 radon for 6 h. Radon inhalation significantly increased total glutathione (t-GSH) content and glutathione peroxidase (GPx) activity in the liver and kidney. Injection of CCl 4 was associated with significantly higher levels of glutamic oxaloacetic transaminase (GOT) and alkaline phosphatase (ALP) activity and creatinine level in serum, and pretreatment with radon significantly decreased the GOT and ALP activity and creatinine level associated with CCl 4 injection, suggesting that radon inhalation alleviates CCl 4-induced hepatic and renal damage. The t-GSH contents and GPx activity in the liver and kidney of animals pretreated with radon were significantly higher than those of the CCl 4-only group. These findings suggested that radon inhalation activated antioxidative functions and inhibited CCl 4-induced hepatic and renal damage in mice.",

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AU - Sakoda, Akihiro

AU - Ishimori, Yuu

AU - Aoyama, Yutaka

AU - Taguchi, Takehito

AU - Yamaoka, Kiyonori

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AB - We assessed whether radon inhalation provided protection from carbon tetrachloride (CCl 4)-induced hepatic and renal damage in mice. Mice were subjected to intraperitoneal injection of CCl 4 after inhaling approximately 18 kBq/m 3 radon for 6 h. Radon inhalation significantly increased total glutathione (t-GSH) content and glutathione peroxidase (GPx) activity in the liver and kidney. Injection of CCl 4 was associated with significantly higher levels of glutamic oxaloacetic transaminase (GOT) and alkaline phosphatase (ALP) activity and creatinine level in serum, and pretreatment with radon significantly decreased the GOT and ALP activity and creatinine level associated with CCl 4 injection, suggesting that radon inhalation alleviates CCl 4-induced hepatic and renal damage. The t-GSH contents and GPx activity in the liver and kidney of animals pretreated with radon were significantly higher than those of the CCl 4-only group. These findings suggested that radon inhalation activated antioxidative functions and inhibited CCl 4-induced hepatic and renal damage in mice.

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KW - liver

KW - radon inhalation

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Radon inhalation protects mice from carbon-tetrachloride-induced hepatic and renal damage

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