Abstract
We assessed whether radon inhalation provided protection from carbon tetrachloride (CCl 4)-induced hepatic and renal damage in mice. Mice were subjected to intraperitoneal injection of CCl 4 after inhaling approximately 18 kBq/m 3 radon for 6 h. Radon inhalation significantly increased total glutathione (t-GSH) content and glutathione peroxidase (GPx) activity in the liver and kidney. Injection of CCl 4 was associated with significantly higher levels of glutamic oxaloacetic transaminase (GOT) and alkaline phosphatase (ALP) activity and creatinine level in serum, and pretreatment with radon significantly decreased the GOT and ALP activity and creatinine level associated with CCl 4 injection, suggesting that radon inhalation alleviates CCl 4-induced hepatic and renal damage. The t-GSH contents and GPx activity in the liver and kidney of animals pretreated with radon were significantly higher than those of the CCl 4-only group. These findings suggested that radon inhalation activated antioxidative functions and inhibited CCl 4-induced hepatic and renal damage in mice.
| Original language | English |
|---|---|
| Pages (from-to) | 559-567 |
| Number of pages | 9 |
| Journal | Inflammation |
| Volume | 34 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 2011 |
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Keywords
- antioxidative function
- carbon tetrachloride
- kidney
- liver
- radon inhalation
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
Cite this
Radon inhalation protects mice from carbon-tetrachloride-induced hepatic and renal damage. / Kataoka, Takahiro; Nishiyama, Yuichi; Toyota, Teruaki; Yoshimoto, Masaaki; Sakoda, Akihiro; Ishimori, Yuu; Aoyama, Yutaka; Taguchi, Takehito; Yamaoka, Kiyonori.
In: Inflammation, Vol. 34, No. 6, 12.2011, p. 559-567.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Radon inhalation protects mice from carbon-tetrachloride-induced hepatic and renal damage
AU - Kataoka, Takahiro
AU - Nishiyama, Yuichi
AU - Toyota, Teruaki
AU - Yoshimoto, Masaaki
AU - Sakoda, Akihiro
AU - Ishimori, Yuu
AU - Aoyama, Yutaka
AU - Taguchi, Takehito
AU - Yamaoka, Kiyonori
PY - 2011/12
Y1 - 2011/12
N2 - We assessed whether radon inhalation provided protection from carbon tetrachloride (CCl 4)-induced hepatic and renal damage in mice. Mice were subjected to intraperitoneal injection of CCl 4 after inhaling approximately 18 kBq/m 3 radon for 6 h. Radon inhalation significantly increased total glutathione (t-GSH) content and glutathione peroxidase (GPx) activity in the liver and kidney. Injection of CCl 4 was associated with significantly higher levels of glutamic oxaloacetic transaminase (GOT) and alkaline phosphatase (ALP) activity and creatinine level in serum, and pretreatment with radon significantly decreased the GOT and ALP activity and creatinine level associated with CCl 4 injection, suggesting that radon inhalation alleviates CCl 4-induced hepatic and renal damage. The t-GSH contents and GPx activity in the liver and kidney of animals pretreated with radon were significantly higher than those of the CCl 4-only group. These findings suggested that radon inhalation activated antioxidative functions and inhibited CCl 4-induced hepatic and renal damage in mice.
AB - We assessed whether radon inhalation provided protection from carbon tetrachloride (CCl 4)-induced hepatic and renal damage in mice. Mice were subjected to intraperitoneal injection of CCl 4 after inhaling approximately 18 kBq/m 3 radon for 6 h. Radon inhalation significantly increased total glutathione (t-GSH) content and glutathione peroxidase (GPx) activity in the liver and kidney. Injection of CCl 4 was associated with significantly higher levels of glutamic oxaloacetic transaminase (GOT) and alkaline phosphatase (ALP) activity and creatinine level in serum, and pretreatment with radon significantly decreased the GOT and ALP activity and creatinine level associated with CCl 4 injection, suggesting that radon inhalation alleviates CCl 4-induced hepatic and renal damage. The t-GSH contents and GPx activity in the liver and kidney of animals pretreated with radon were significantly higher than those of the CCl 4-only group. These findings suggested that radon inhalation activated antioxidative functions and inhibited CCl 4-induced hepatic and renal damage in mice.
KW - antioxidative function
KW - carbon tetrachloride
KW - kidney
KW - liver
KW - radon inhalation
UR - http://www.scopus.com/inward/record.url?scp=82955240793&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=82955240793&partnerID=8YFLogxK
U2 - 10.1007/s10753-010-9263-7
DO - 10.1007/s10753-010-9263-7
M3 - Article
C2 - 20890648
AN - SCOPUS:82955240793
VL - 34
SP - 559
EP - 567
JO - Inflammation
JF - Inflammation
SN - 0360-3997
IS - 6
ER -