TY - JOUR
T1 - Radon Inhalation Protects Against Transient Global Cerebral Ischemic Injury in Gerbils
AU - Kataoka, Takahiro
AU - Etani, Reo
AU - Takata, Yuji
AU - Nishiyama, Yuichi
AU - Kawabe, Atsushi
AU - Kumashiro, Masayuki
AU - Taguchi, Takehito
AU - Yamaoka, Kiyonori
N1 - Funding Information:
This research was supported by a Grant-In-Aid for Young Scientists (B) from MEXT (No. 25820449).
PY - 2014/9/24
Y1 - 2014/9/24
N2 - Although brain disorders are not the main indication for radon therapy, our previous study suggested that radon inhalation therapy might mitigate brain disorders. In this study, we assessed whether radon inhalation protects against transient global cerebral ischemic injury in gerbils. Gerbils were treated with inhaled radon at a concentration of 2,000 Bq/m3 for 24 h. After radon inhalation, transient global cerebral ischemia was induced by bilateral occlusion of the common carotid artery. Results showed that transient global cerebral ischemia induced neuronal damage in hippocampal CA1, and the number of damaged neurons was significantly increased compared with control. However, radon treatment inhibited ischemic damage. Superoxide dismutase (SOD) activity in the radon-treated gerbil brain was significantly higher than that in sham-operated gerbils. These findings suggested that radon inhalation activates antioxidative function, especially SOD, thereby inhibiting transient global cerebral ischemic injury in gerbils.
AB - Although brain disorders are not the main indication for radon therapy, our previous study suggested that radon inhalation therapy might mitigate brain disorders. In this study, we assessed whether radon inhalation protects against transient global cerebral ischemic injury in gerbils. Gerbils were treated with inhaled radon at a concentration of 2,000 Bq/m3 for 24 h. After radon inhalation, transient global cerebral ischemia was induced by bilateral occlusion of the common carotid artery. Results showed that transient global cerebral ischemia induced neuronal damage in hippocampal CA1, and the number of damaged neurons was significantly increased compared with control. However, radon treatment inhibited ischemic damage. Superoxide dismutase (SOD) activity in the radon-treated gerbil brain was significantly higher than that in sham-operated gerbils. These findings suggested that radon inhalation activates antioxidative function, especially SOD, thereby inhibiting transient global cerebral ischemic injury in gerbils.
KW - antioxidative function
KW - radon inhalation
KW - transient global cerebral ischemic injury
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U2 - 10.1007/s10753-014-9896-z
DO - 10.1007/s10753-014-9896-z
M3 - Article
C2 - 24792782
AN - SCOPUS:84918820079
VL - 37
SP - 1675
EP - 1682
JO - Inflammation
JF - Inflammation
SN - 0360-3997
IS - 5
ER -