Radon Inhalation Protects Against Transient Global Cerebral Ischemic Injury in Gerbils

Takahiro Kataoka, Reo Etani, Yuji Takata, Yuichi Nishiyama, Atsushi Kawabe, Masayuki Kumashiro, Takehito Taguchi, Kiyonori Yamaoka

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Although brain disorders are not the main indication for radon therapy, our previous study suggested that radon inhalation therapy might mitigate brain disorders. In this study, we assessed whether radon inhalation protects against transient global cerebral ischemic injury in gerbils. Gerbils were treated with inhaled radon at a concentration of 2,000 Bq/m3 for 24 h. After radon inhalation, transient global cerebral ischemia was induced by bilateral occlusion of the common carotid artery. Results showed that transient global cerebral ischemia induced neuronal damage in hippocampal CA1, and the number of damaged neurons was significantly increased compared with control. However, radon treatment inhibited ischemic damage. Superoxide dismutase (SOD) activity in the radon-treated gerbil brain was significantly higher than that in sham-operated gerbils. These findings suggested that radon inhalation activates antioxidative function, especially SOD, thereby inhibiting transient global cerebral ischemic injury in gerbils.

Original languageEnglish
Pages (from-to)1675-1682
Number of pages8
JournalInflammation
Volume37
Issue number5
DOIs
Publication statusPublished - Sep 24 2014

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Keywords

  • antioxidative function
  • radon inhalation
  • transient global cerebral ischemic injury

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

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