Radionuclide imaging of neurohormonal system of the heart

Xinyu Chen, Rudolf A. Werner, Mehrbod S. Javadi, Yoshifumi Maya, Michael Decker, Constantin Lapa, Ken Herrmann, Takahiro Higuchi

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Heart failure is one of the growing causes of death especially in developed countries due to longer life expectancy. Although many pharmacological and instrumental therapeutic approaches have been introduced for prevention and treatment of heart failure, there are still limitations and challenges. Nuclear cardiology has experienced rapid growth in the last few decades, in particular the application of single photon emission computed tomography (SPECT) and positron emission tomography (PET), which allow non-invasive functional assessment of cardiac condition including neurohormonal systems involved in heart failure; its application has dramatically improved the capacity for fundamental research and clinical diagnosis. In this article, we review the current status of applying radionuclide technology in non-invasive imaging of neurohormonal system in the heart, especially focusing on the tracers that are currently available. A short discussion about disadvantages and perspectives is also included.

Original languageEnglish
Pages (from-to)545-558
Number of pages14
JournalTheranostics
Volume5
Issue number6
DOIs
Publication statusPublished - Jan 1 2015
Externally publishedYes

Fingerprint

Radionuclide Imaging
Heart Failure
Life Expectancy
Single-Photon Emission-Computed Tomography
Cardiology
Treatment Failure
Developed Countries
Radioisotopes
Positron-Emission Tomography
Cause of Death
Pharmacology
Technology
Growth
Research
Therapeutics

Keywords

  • Cardiac neurohormonal system
  • Heart failure
  • Nuclear cardiology
  • PET
  • Radiotracer
  • SPECT

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Cite this

Chen, X., Werner, R. A., Javadi, M. S., Maya, Y., Decker, M., Lapa, C., ... Higuchi, T. (2015). Radionuclide imaging of neurohormonal system of the heart. Theranostics, 5(6), 545-558. https://doi.org/10.7150/thno.10900

Radionuclide imaging of neurohormonal system of the heart. / Chen, Xinyu; Werner, Rudolf A.; Javadi, Mehrbod S.; Maya, Yoshifumi; Decker, Michael; Lapa, Constantin; Herrmann, Ken; Higuchi, Takahiro.

In: Theranostics, Vol. 5, No. 6, 01.01.2015, p. 545-558.

Research output: Contribution to journalReview article

Chen, X, Werner, RA, Javadi, MS, Maya, Y, Decker, M, Lapa, C, Herrmann, K & Higuchi, T 2015, 'Radionuclide imaging of neurohormonal system of the heart', Theranostics, vol. 5, no. 6, pp. 545-558. https://doi.org/10.7150/thno.10900
Chen X, Werner RA, Javadi MS, Maya Y, Decker M, Lapa C et al. Radionuclide imaging of neurohormonal system of the heart. Theranostics. 2015 Jan 1;5(6):545-558. https://doi.org/10.7150/thno.10900
Chen, Xinyu ; Werner, Rudolf A. ; Javadi, Mehrbod S. ; Maya, Yoshifumi ; Decker, Michael ; Lapa, Constantin ; Herrmann, Ken ; Higuchi, Takahiro. / Radionuclide imaging of neurohormonal system of the heart. In: Theranostics. 2015 ; Vol. 5, No. 6. pp. 545-558.
@article{266dc1325ffd4baca61c22741ef821df,
title = "Radionuclide imaging of neurohormonal system of the heart",
abstract = "Heart failure is one of the growing causes of death especially in developed countries due to longer life expectancy. Although many pharmacological and instrumental therapeutic approaches have been introduced for prevention and treatment of heart failure, there are still limitations and challenges. Nuclear cardiology has experienced rapid growth in the last few decades, in particular the application of single photon emission computed tomography (SPECT) and positron emission tomography (PET), which allow non-invasive functional assessment of cardiac condition including neurohormonal systems involved in heart failure; its application has dramatically improved the capacity for fundamental research and clinical diagnosis. In this article, we review the current status of applying radionuclide technology in non-invasive imaging of neurohormonal system in the heart, especially focusing on the tracers that are currently available. A short discussion about disadvantages and perspectives is also included.",
keywords = "Cardiac neurohormonal system, Heart failure, Nuclear cardiology, PET, Radiotracer, SPECT",
author = "Xinyu Chen and Werner, {Rudolf A.} and Javadi, {Mehrbod S.} and Yoshifumi Maya and Michael Decker and Constantin Lapa and Ken Herrmann and Takahiro Higuchi",
year = "2015",
month = "1",
day = "1",
doi = "10.7150/thno.10900",
language = "English",
volume = "5",
pages = "545--558",
journal = "Theranostics",
issn = "1838-7640",
publisher = "Ivyspring International Publisher",
number = "6",

}

TY - JOUR

T1 - Radionuclide imaging of neurohormonal system of the heart

AU - Chen, Xinyu

AU - Werner, Rudolf A.

AU - Javadi, Mehrbod S.

AU - Maya, Yoshifumi

AU - Decker, Michael

AU - Lapa, Constantin

AU - Herrmann, Ken

AU - Higuchi, Takahiro

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Heart failure is one of the growing causes of death especially in developed countries due to longer life expectancy. Although many pharmacological and instrumental therapeutic approaches have been introduced for prevention and treatment of heart failure, there are still limitations and challenges. Nuclear cardiology has experienced rapid growth in the last few decades, in particular the application of single photon emission computed tomography (SPECT) and positron emission tomography (PET), which allow non-invasive functional assessment of cardiac condition including neurohormonal systems involved in heart failure; its application has dramatically improved the capacity for fundamental research and clinical diagnosis. In this article, we review the current status of applying radionuclide technology in non-invasive imaging of neurohormonal system in the heart, especially focusing on the tracers that are currently available. A short discussion about disadvantages and perspectives is also included.

AB - Heart failure is one of the growing causes of death especially in developed countries due to longer life expectancy. Although many pharmacological and instrumental therapeutic approaches have been introduced for prevention and treatment of heart failure, there are still limitations and challenges. Nuclear cardiology has experienced rapid growth in the last few decades, in particular the application of single photon emission computed tomography (SPECT) and positron emission tomography (PET), which allow non-invasive functional assessment of cardiac condition including neurohormonal systems involved in heart failure; its application has dramatically improved the capacity for fundamental research and clinical diagnosis. In this article, we review the current status of applying radionuclide technology in non-invasive imaging of neurohormonal system in the heart, especially focusing on the tracers that are currently available. A short discussion about disadvantages and perspectives is also included.

KW - Cardiac neurohormonal system

KW - Heart failure

KW - Nuclear cardiology

KW - PET

KW - Radiotracer

KW - SPECT

UR - http://www.scopus.com/inward/record.url?scp=84930631173&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930631173&partnerID=8YFLogxK

U2 - 10.7150/thno.10900

DO - 10.7150/thno.10900

M3 - Review article

C2 - 25825596

AN - SCOPUS:84930631173

VL - 5

SP - 545

EP - 558

JO - Theranostics

JF - Theranostics

SN - 1838-7640

IS - 6

ER -