Abstract
PURPOSE: The present study was performed to evaluate the effect of pulmonary artery embolization on radiofrequency (RF) ablation of normal porcine lungs. MATERIALS AND METHODS: RF ablation zones (n = 34) were created in the normal lungs of five domestic pigs (five zones in each of the first two pigs and eight zones in each of the remaining three pigs) with an expandable multitined electrode with use of bilateral thoracotomy. RF ablation was performed without pulmonary artery embolization (group 1, n = 8), immediately after embolization (group 2, n = 11), 15 minutes after embolization (group 3, n = 7), and 30 minutes after embolization (group 4, n = 8) with degradable starch microspheres. Among them, 12 ablation zones were excluded from this study because they were considerably limited by the presence of the pleura or large bronchi. The remaining 22 zones were included (n = 7, n = 5, n= 4, and n = 6 in groups 1, 2, 3, and 4, respectively). Coagulation necrosis volumes in the ablation zones were measured and compared among the groups. RESULTS: Coagulation necrosis volumes were 0.9 ± 0.5 cm, 2.1 ± 0.4 cm, 2.1 ± 1.0 cm, and 1.9 ± 0.6 cm in groups 1, 2, 3, and 4, respectively. Groups 2-4 showed significantly larger coagulation volumes than group 1 (P = .012, P = .023, and P = .010 in groups 2, 3, and 4, respectively). CONCLUSION: Pulmonary artery embolization contributed to larger volumes of coagulation necrosis after RF ablation of normal lungs.
| Original language | English |
|---|---|
| Pages (from-to) | 1991-1998 |
| Number of pages | 8 |
| Journal | Journal of Vascular and Interventional Radiology |
| Volume | 17 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 2006 |
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ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
Radiofrequency ablation of normal lungs after pulmonary artery embolization with use of degradable starch microspheres : Results in a porcine model. / Hiraki, Takao; Gobara, Hideo; Sakurai, Jun; Mimura, Hidefumi; Mukai, Takashi; Hase, Soichiro; Iguchi, Toshihiro; Fujiwara, Hiroyasu; Tajiri, Nobuhisa; Yanai, Hiroyuki; Yoshino, Tadashi; Kanazawa, Susumu.
In: Journal of Vascular and Interventional Radiology, Vol. 17, No. 12, 12.2006, p. 1991-1998.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Radiofrequency ablation of normal lungs after pulmonary artery embolization with use of degradable starch microspheres
T2 - Results in a porcine model
AU - Hiraki, Takao
AU - Gobara, Hideo
AU - Sakurai, Jun
AU - Mimura, Hidefumi
AU - Mukai, Takashi
AU - Hase, Soichiro
AU - Iguchi, Toshihiro
AU - Fujiwara, Hiroyasu
AU - Tajiri, Nobuhisa
AU - Yanai, Hiroyuki
AU - Yoshino, Tadashi
AU - Kanazawa, Susumu
PY - 2006/12
Y1 - 2006/12
N2 - PURPOSE: The present study was performed to evaluate the effect of pulmonary artery embolization on radiofrequency (RF) ablation of normal porcine lungs. MATERIALS AND METHODS: RF ablation zones (n = 34) were created in the normal lungs of five domestic pigs (five zones in each of the first two pigs and eight zones in each of the remaining three pigs) with an expandable multitined electrode with use of bilateral thoracotomy. RF ablation was performed without pulmonary artery embolization (group 1, n = 8), immediately after embolization (group 2, n = 11), 15 minutes after embolization (group 3, n = 7), and 30 minutes after embolization (group 4, n = 8) with degradable starch microspheres. Among them, 12 ablation zones were excluded from this study because they were considerably limited by the presence of the pleura or large bronchi. The remaining 22 zones were included (n = 7, n = 5, n= 4, and n = 6 in groups 1, 2, 3, and 4, respectively). Coagulation necrosis volumes in the ablation zones were measured and compared among the groups. RESULTS: Coagulation necrosis volumes were 0.9 ± 0.5 cm, 2.1 ± 0.4 cm, 2.1 ± 1.0 cm, and 1.9 ± 0.6 cm in groups 1, 2, 3, and 4, respectively. Groups 2-4 showed significantly larger coagulation volumes than group 1 (P = .012, P = .023, and P = .010 in groups 2, 3, and 4, respectively). CONCLUSION: Pulmonary artery embolization contributed to larger volumes of coagulation necrosis after RF ablation of normal lungs.
AB - PURPOSE: The present study was performed to evaluate the effect of pulmonary artery embolization on radiofrequency (RF) ablation of normal porcine lungs. MATERIALS AND METHODS: RF ablation zones (n = 34) were created in the normal lungs of five domestic pigs (five zones in each of the first two pigs and eight zones in each of the remaining three pigs) with an expandable multitined electrode with use of bilateral thoracotomy. RF ablation was performed without pulmonary artery embolization (group 1, n = 8), immediately after embolization (group 2, n = 11), 15 minutes after embolization (group 3, n = 7), and 30 minutes after embolization (group 4, n = 8) with degradable starch microspheres. Among them, 12 ablation zones were excluded from this study because they were considerably limited by the presence of the pleura or large bronchi. The remaining 22 zones were included (n = 7, n = 5, n= 4, and n = 6 in groups 1, 2, 3, and 4, respectively). Coagulation necrosis volumes in the ablation zones were measured and compared among the groups. RESULTS: Coagulation necrosis volumes were 0.9 ± 0.5 cm, 2.1 ± 0.4 cm, 2.1 ± 1.0 cm, and 1.9 ± 0.6 cm in groups 1, 2, 3, and 4, respectively. Groups 2-4 showed significantly larger coagulation volumes than group 1 (P = .012, P = .023, and P = .010 in groups 2, 3, and 4, respectively). CONCLUSION: Pulmonary artery embolization contributed to larger volumes of coagulation necrosis after RF ablation of normal lungs.
UR - http://www.scopus.com/inward/record.url?scp=33847689821&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33847689821&partnerID=8YFLogxK
U2 - 10.1097/01.RVI.0000251152.12254.ac
DO - 10.1097/01.RVI.0000251152.12254.ac
M3 - Article
C2 - 17185698
AN - SCOPUS:33847689821
VL - 17
SP - 1991
EP - 1998
JO - Journal of Vascular and Interventional Radiology
JF - Journal of Vascular and Interventional Radiology
SN - 1051-0443
IS - 12
ER -