Radical surgery after successful chemotherapy in a case of primary small cell carcinoma of the liver

Yutaka Akimoto, Koichiro Tsutsumi, Hironari Kato, Hidenori Hata, Hiroyuki Sakae, Daisuke Uchida, Takeshi Tomoda, Kazuyuki Matsumoto, Yasuhiro Noma, Naoki Yamamoto, Shigeru Horiguchi, Ryo Harada, Hiroyuki Okada, Hiroyuki Yanai, Takahito Yagi, Kazuhide Yamamoto

Research output: Contribution to journalArticle

Abstract

A 52-year-old woman was admitted to our hospital with right upper quadrant pain with gallbladder wall thickening and multiple liver tumors. Endoscopic ultrasound-guided biopsy revealed small cell carcinomas of both the gallbladder and liver. After 10 cycles of chemotherapy with etoposide and cisplatin, marked shrinkage of the tumors was evident on computed tomography. The patient subsequently underwent hepatectomy and resection of the extrahepatic bile duct and gallbladder with curative intent. Although no viable tumor cells were found in the resected specimens, we confirmed phagocytosis of tumor cells killed by chemotherapy in the resected liver specimen. Therefore, we suspected that the patient had primary small cell carcinoma of the liver that had been successfully treated. This is a rare case of primary small cell carcinoma of the liver that showed pathological complete response to chemotherapy with etoposide and cisplatin.

Original languageEnglish
Pages (from-to)2024-2034
Number of pages11
JournalJapanese Journal of Gastroenterology
Volume112
Issue number11
DOIs
Publication statusPublished - Nov 1 2015

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Small Cell Carcinoma
Drug Therapy
Gallbladder
Liver
Etoposide
Cisplatin
Neoplasms
Extrahepatic Bile Ducts
Cytophagocytosis
Hepatectomy
Tomography
Biopsy
Pain

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Radical surgery after successful chemotherapy in a case of primary small cell carcinoma of the liver. / Akimoto, Yutaka; Tsutsumi, Koichiro; Kato, Hironari; Hata, Hidenori; Sakae, Hiroyuki; Uchida, Daisuke; Tomoda, Takeshi; Matsumoto, Kazuyuki; Noma, Yasuhiro; Yamamoto, Naoki; Horiguchi, Shigeru; Harada, Ryo; Okada, Hiroyuki; Yanai, Hiroyuki; Yagi, Takahito; Yamamoto, Kazuhide.

In: Japanese Journal of Gastroenterology, Vol. 112, No. 11, 01.11.2015, p. 2024-2034.

Research output: Contribution to journalArticle

Akimoto, Yutaka ; Tsutsumi, Koichiro ; Kato, Hironari ; Hata, Hidenori ; Sakae, Hiroyuki ; Uchida, Daisuke ; Tomoda, Takeshi ; Matsumoto, Kazuyuki ; Noma, Yasuhiro ; Yamamoto, Naoki ; Horiguchi, Shigeru ; Harada, Ryo ; Okada, Hiroyuki ; Yanai, Hiroyuki ; Yagi, Takahito ; Yamamoto, Kazuhide. / Radical surgery after successful chemotherapy in a case of primary small cell carcinoma of the liver. In: Japanese Journal of Gastroenterology. 2015 ; Vol. 112, No. 11. pp. 2024-2034.
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AU - Tomoda, Takeshi

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