Abstract
A 52-year-old woman was admitted to our hospital with right upper quadrant pain with gallbladder wall thickening and multiple liver tumors. Endoscopic ultrasound-guided biopsy revealed small cell carcinomas of both the gallbladder and liver. After 10 cycles of chemotherapy with etoposide and cisplatin, marked shrinkage of the tumors was evident on computed tomography. The patient subsequently underwent hepatectomy and resection of the extrahepatic bile duct and gallbladder with curative intent. Although no viable tumor cells were found in the resected specimens, we confirmed phagocytosis of tumor cells killed by chemotherapy in the resected liver specimen. Therefore, we suspected that the patient had primary small cell carcinoma of the liver that had been successfully treated. This is a rare case of primary small cell carcinoma of the liver that showed pathological complete response to chemotherapy with etoposide and cisplatin.
| Original language | English |
|---|---|
| Pages (from-to) | 2024-2034 |
| Number of pages | 11 |
| Journal | Japanese Journal of Gastroenterology |
| Volume | 112 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 1 2015 |
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ASJC Scopus subject areas
- Gastroenterology
Cite this
Radical surgery after successful chemotherapy in a case of primary small cell carcinoma of the liver. / Akimoto, Yutaka; Tsutsumi, Koichiro; Kato, Hironari; Hata, Hidenori; Sakae, Hiroyuki; Uchida, Daisuke; Tomoda, Takeshi; Matsumoto, Kazuyuki; Noma, Yasuhiro; Yamamoto, Naoki; Horiguchi, Shigeru; Harada, Ryo; Okada, Hiroyuki; Yanai, Hiroyuki; Yagi, Takahito; Yamamoto, Kazuhide.
In: Japanese Journal of Gastroenterology, Vol. 112, No. 11, 01.11.2015, p. 2024-2034.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Radical surgery after successful chemotherapy in a case of primary small cell carcinoma of the liver
AU - Akimoto, Yutaka
AU - Tsutsumi, Koichiro
AU - Kato, Hironari
AU - Hata, Hidenori
AU - Sakae, Hiroyuki
AU - Uchida, Daisuke
AU - Tomoda, Takeshi
AU - Matsumoto, Kazuyuki
AU - Noma, Yasuhiro
AU - Yamamoto, Naoki
AU - Horiguchi, Shigeru
AU - Harada, Ryo
AU - Okada, Hiroyuki
AU - Yanai, Hiroyuki
AU - Yagi, Takahito
AU - Yamamoto, Kazuhide
PY - 2015/11/1
Y1 - 2015/11/1
N2 - A 52-year-old woman was admitted to our hospital with right upper quadrant pain with gallbladder wall thickening and multiple liver tumors. Endoscopic ultrasound-guided biopsy revealed small cell carcinomas of both the gallbladder and liver. After 10 cycles of chemotherapy with etoposide and cisplatin, marked shrinkage of the tumors was evident on computed tomography. The patient subsequently underwent hepatectomy and resection of the extrahepatic bile duct and gallbladder with curative intent. Although no viable tumor cells were found in the resected specimens, we confirmed phagocytosis of tumor cells killed by chemotherapy in the resected liver specimen. Therefore, we suspected that the patient had primary small cell carcinoma of the liver that had been successfully treated. This is a rare case of primary small cell carcinoma of the liver that showed pathological complete response to chemotherapy with etoposide and cisplatin.
AB - A 52-year-old woman was admitted to our hospital with right upper quadrant pain with gallbladder wall thickening and multiple liver tumors. Endoscopic ultrasound-guided biopsy revealed small cell carcinomas of both the gallbladder and liver. After 10 cycles of chemotherapy with etoposide and cisplatin, marked shrinkage of the tumors was evident on computed tomography. The patient subsequently underwent hepatectomy and resection of the extrahepatic bile duct and gallbladder with curative intent. Although no viable tumor cells were found in the resected specimens, we confirmed phagocytosis of tumor cells killed by chemotherapy in the resected liver specimen. Therefore, we suspected that the patient had primary small cell carcinoma of the liver that had been successfully treated. This is a rare case of primary small cell carcinoma of the liver that showed pathological complete response to chemotherapy with etoposide and cisplatin.
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U2 - 10.11405/nisshoshi.112.2024
DO - 10.11405/nisshoshi.112.2024
M3 - Article
VL - 112
SP - 2024
EP - 2034
JO - Japanese Journal of Gastroenterology
JF - Japanese Journal of Gastroenterology
SN - 0446-6586
IS - 11
ER -