Radiation-induced peroxidation of lipid dissolved in organic solvent and its inhibition by alpha-tocopherol and cepharanthine.

N. Shiraishi, I. Joja, Masahiro Kuroda, M. Fujishima, M. Miyake, K. Aono

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Effects of cepharanthine and alpha-tocopherol on radiation-induced peroxidation of lipids dissolved in methanol(MeOH)-chloroform (CHCl3)-H2O(v/v, 2/1/0.8) were examined. alpha-Tocopherol strongly inhibited radiation-induced peroxidation of lipids dissolved in MeOH-CHCl3-H2O. However, cepharanthine exhibited a weak inhibitory action in this system. The change in the absorption spectrum of alpha-tocopherol and cepharanthine by X-irradiation was measured. The reagents were dissolved in 95% EtOH acidified with 20 mM HCl and in MeOH-CHCl3-H2O. alpha-Tocopherol exhibited the change in its absorption spectrum in both systems, and seemed to be oxidized at a high rate by free radicals. However, cepharanthine slightly exhibited the change in its spectrum in MeOH-CHCl3-H2O, but not in acidified EtOH.

Original languageEnglish
Pages (from-to)243-246
Number of pages4
JournalPhysiological Chemistry and Physics and Medical NMR
Volume17
Issue number3
Publication statusPublished - 1985
Externally publishedYes

Fingerprint

alpha-Tocopherol
Organic solvents
Lipid Peroxidation
Radiation
Lipids
Absorption spectra
Chloroform
Free Radicals
Methanol
Irradiation
cepharanthine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biophysics
  • Physiology
  • Physiology (medical)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Radiation-induced peroxidation of lipid dissolved in organic solvent and its inhibition by alpha-tocopherol and cepharanthine. / Shiraishi, N.; Joja, I.; Kuroda, Masahiro; Fujishima, M.; Miyake, M.; Aono, K.

In: Physiological Chemistry and Physics and Medical NMR, Vol. 17, No. 3, 1985, p. 243-246.

Research output: Contribution to journalArticle

@article{f2304a48296244d1bf4ae2e77a6ce212,
title = "Radiation-induced peroxidation of lipid dissolved in organic solvent and its inhibition by alpha-tocopherol and cepharanthine.",
abstract = "Effects of cepharanthine and alpha-tocopherol on radiation-induced peroxidation of lipids dissolved in methanol(MeOH)-chloroform (CHCl3)-H2O(v/v, 2/1/0.8) were examined. alpha-Tocopherol strongly inhibited radiation-induced peroxidation of lipids dissolved in MeOH-CHCl3-H2O. However, cepharanthine exhibited a weak inhibitory action in this system. The change in the absorption spectrum of alpha-tocopherol and cepharanthine by X-irradiation was measured. The reagents were dissolved in 95{\%} EtOH acidified with 20 mM HCl and in MeOH-CHCl3-H2O. alpha-Tocopherol exhibited the change in its absorption spectrum in both systems, and seemed to be oxidized at a high rate by free radicals. However, cepharanthine slightly exhibited the change in its spectrum in MeOH-CHCl3-H2O, but not in acidified EtOH.",
author = "N. Shiraishi and I. Joja and Masahiro Kuroda and M. Fujishima and M. Miyake and K. Aono",
year = "1985",
language = "English",
volume = "17",
pages = "243--246",
journal = "Physiological chemistry and physics",
issn = "0748-6642",
publisher = "Pacific Press Inc.",
number = "3",

}

TY - JOUR

T1 - Radiation-induced peroxidation of lipid dissolved in organic solvent and its inhibition by alpha-tocopherol and cepharanthine.

AU - Shiraishi, N.

AU - Joja, I.

AU - Kuroda, Masahiro

AU - Fujishima, M.

AU - Miyake, M.

AU - Aono, K.

PY - 1985

Y1 - 1985

N2 - Effects of cepharanthine and alpha-tocopherol on radiation-induced peroxidation of lipids dissolved in methanol(MeOH)-chloroform (CHCl3)-H2O(v/v, 2/1/0.8) were examined. alpha-Tocopherol strongly inhibited radiation-induced peroxidation of lipids dissolved in MeOH-CHCl3-H2O. However, cepharanthine exhibited a weak inhibitory action in this system. The change in the absorption spectrum of alpha-tocopherol and cepharanthine by X-irradiation was measured. The reagents were dissolved in 95% EtOH acidified with 20 mM HCl and in MeOH-CHCl3-H2O. alpha-Tocopherol exhibited the change in its absorption spectrum in both systems, and seemed to be oxidized at a high rate by free radicals. However, cepharanthine slightly exhibited the change in its spectrum in MeOH-CHCl3-H2O, but not in acidified EtOH.

AB - Effects of cepharanthine and alpha-tocopherol on radiation-induced peroxidation of lipids dissolved in methanol(MeOH)-chloroform (CHCl3)-H2O(v/v, 2/1/0.8) were examined. alpha-Tocopherol strongly inhibited radiation-induced peroxidation of lipids dissolved in MeOH-CHCl3-H2O. However, cepharanthine exhibited a weak inhibitory action in this system. The change in the absorption spectrum of alpha-tocopherol and cepharanthine by X-irradiation was measured. The reagents were dissolved in 95% EtOH acidified with 20 mM HCl and in MeOH-CHCl3-H2O. alpha-Tocopherol exhibited the change in its absorption spectrum in both systems, and seemed to be oxidized at a high rate by free radicals. However, cepharanthine slightly exhibited the change in its spectrum in MeOH-CHCl3-H2O, but not in acidified EtOH.

UR - http://www.scopus.com/inward/record.url?scp=0022336045&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022336045&partnerID=8YFLogxK

M3 - Article

C2 - 4095167

AN - SCOPUS:0022336045

VL - 17

SP - 243

EP - 246

JO - Physiological chemistry and physics

JF - Physiological chemistry and physics

SN - 0748-6642

IS - 3

ER -