Quinolone analogues 10: Synthesis of antimalarial quinolones having pyridyl moiety in N1-side chain

Yoshihisa Kurasawa, Kiminari Yoshida, Naoki Yamazaki, Eisuke Kaji, Kenji Sasaki, Yoshiko Hiwasa, Akiko Tsukamoto, Hideyuki Itoc

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Abstract

Novel 4-quinolone-3-carboxylates 6,7 and 4-quinolone-3-carboxylic acids 8-11 were synthesized from 4-hydroxyquinoline-3-carboxylates. Ethyl 1-[1-ethoxycarbonyl-2-(4-pyridyl)vinyl]-6-fluoro-4-oxoquinoline-3-carboxylate 7a was found to show antimalarial activity from the screening data.

Original languageEnglish
Pages (from-to)657-663
Number of pages7
JournalJournal of Heterocyclic Chemistry
Volume47
Issue number3
DOIs
Publication statusPublished - May 1 2010

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ASJC Scopus subject areas

  • Organic Chemistry

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