Quinolone analogues 10: Synthesis of antimalarial quinolones having pyridyl moiety in N1-side chain

Yoshihisa Kurasawa, Kiminari Yoshida, Naoki Yamazaki, Eisuke Kaji, Kenji Sasaki, Yoshiko Hiwasa, Akiko Tsukamoto, Hideyuki Itoc

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Novel 4-quinolone-3-carboxylates 6,7 and 4-quinolone-3-carboxylic acids 8-11 were synthesized from 4-hydroxyquinoline-3-carboxylates. Ethyl 1-[1-ethoxycarbonyl-2-(4-pyridyl)vinyl]-6-fluoro-4-oxoquinoline-3-carboxylate 7a was found to show antimalarial activity from the screening data.

Original languageEnglish
Pages (from-to)657-663
Number of pages7
JournalJournal of Heterocyclic Chemistry
Volume47
Issue number3
DOIs
Publication statusPublished - May 2010

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4-Quinolones
Quinolones
Antimalarials
Screening

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Quinolone analogues 10 : Synthesis of antimalarial quinolones having pyridyl moiety in N1-side chain. / Kurasawa, Yoshihisa; Yoshida, Kiminari; Yamazaki, Naoki; Kaji, Eisuke; Sasaki, Kenji; Hiwasa, Yoshiko; Tsukamoto, Akiko; Itoc, Hideyuki.

In: Journal of Heterocyclic Chemistry, Vol. 47, No. 3, 05.2010, p. 657-663.

Research output: Contribution to journalArticle

Kurasawa, Y, Yoshida, K, Yamazaki, N, Kaji, E, Sasaki, K, Hiwasa, Y, Tsukamoto, A & Itoc, H 2010, 'Quinolone analogues 10: Synthesis of antimalarial quinolones having pyridyl moiety in N1-side chain', Journal of Heterocyclic Chemistry, vol. 47, no. 3, pp. 657-663. https://doi.org/10.1002/jhet.297
Kurasawa, Yoshihisa ; Yoshida, Kiminari ; Yamazaki, Naoki ; Kaji, Eisuke ; Sasaki, Kenji ; Hiwasa, Yoshiko ; Tsukamoto, Akiko ; Itoc, Hideyuki. / Quinolone analogues 10 : Synthesis of antimalarial quinolones having pyridyl moiety in N1-side chain. In: Journal of Heterocyclic Chemistry. 2010 ; Vol. 47, No. 3. pp. 657-663.
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