Quantitative study of the vestibular sensory epithelium in cochleosaccular dysplasia

Shin Kariya, Sebahattin Cureoglu, Patricia A. Schachern, Andre L L Sampaio, Michael M. Paparella, Takeshi Kusunoki, Mehmet F. Oktay, Kazunori Nishizaki

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Cochleosaccular dysplasia is the most common pathologic finding seen in children with profound congenital sensorineural hearing loss. There has been no quantitative study on the peripheral vestibular system in cochleosaccular dysplasia. Objective: To investigate quantitatively the extent of pathologic changes of the vestibular sensory epithelium in cochleosaccular dysplasia. Subjects and Methods: Thirteen temporal bones with congenital deafness from 10 individuals were selected for this study from the temporal bone collection of University of Minnesota that showed suitable pathologic findings for the histopathologic criteria of cochleosaccular dysplasia. Age-matched normal control temporal bones were also selected. The vestibular hair cells including types I and II hair cells were counted separately in the saccular macula, utricular macula, and three cristae of the semicircular canals using Nomarski microscopy. Results: The hair cell densities of types I and II hair cells in the macula of the saccule in cochleosaccular dysplasia were significantly decreased compared with the data of normal subjects. Both types I and II hair cells in the utricular macula and the cristae of the three semicircular canals in cochleosaccular dysplasia were well preserved, and no significant difference was observed between findings of cochleosaccular dysplasia and normal controls in the utricle and the three semicircular canals. Conclusions: In cases with cochleosaccular dysplasia, the neurosensorial hair cells of the saccule were affected; however, the osseous labyrinth, the membranous utricle, and the semi-circular canals were normal. Further studies should be performed to establish the pathogenesis of cochleosaccular dysplasia in humans.

Original languageEnglish
Pages (from-to)495-499
Number of pages5
JournalOtology and Neurotology
Volume26
Issue number3
DOIs
Publication statusPublished - May 2005

Fingerprint

Saccule and Utricle
Semicircular Canals
Temporal Bone
Epithelium
Vestibular Hair Cells
Sensorineural Hearing Loss
Deafness
Inner Ear
Microscopy
Cell Count

Keywords

  • Cochleosaccular dysplasia
  • Hair cell
  • Saccule
  • Scheibe's dysplasia
  • Semicircular canal
  • Utricle
  • Vestibule

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Neuroscience(all)

Cite this

Quantitative study of the vestibular sensory epithelium in cochleosaccular dysplasia. / Kariya, Shin; Cureoglu, Sebahattin; Schachern, Patricia A.; Sampaio, Andre L L; Paparella, Michael M.; Kusunoki, Takeshi; Oktay, Mehmet F.; Nishizaki, Kazunori.

In: Otology and Neurotology, Vol. 26, No. 3, 05.2005, p. 495-499.

Research output: Contribution to journalArticle

Kariya, S, Cureoglu, S, Schachern, PA, Sampaio, ALL, Paparella, MM, Kusunoki, T, Oktay, MF & Nishizaki, K 2005, 'Quantitative study of the vestibular sensory epithelium in cochleosaccular dysplasia', Otology and Neurotology, vol. 26, no. 3, pp. 495-499. https://doi.org/10.1097/01.mao.0000169776.69409.f1
Kariya, Shin ; Cureoglu, Sebahattin ; Schachern, Patricia A. ; Sampaio, Andre L L ; Paparella, Michael M. ; Kusunoki, Takeshi ; Oktay, Mehmet F. ; Nishizaki, Kazunori. / Quantitative study of the vestibular sensory epithelium in cochleosaccular dysplasia. In: Otology and Neurotology. 2005 ; Vol. 26, No. 3. pp. 495-499.
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abstract = "Background: Cochleosaccular dysplasia is the most common pathologic finding seen in children with profound congenital sensorineural hearing loss. There has been no quantitative study on the peripheral vestibular system in cochleosaccular dysplasia. Objective: To investigate quantitatively the extent of pathologic changes of the vestibular sensory epithelium in cochleosaccular dysplasia. Subjects and Methods: Thirteen temporal bones with congenital deafness from 10 individuals were selected for this study from the temporal bone collection of University of Minnesota that showed suitable pathologic findings for the histopathologic criteria of cochleosaccular dysplasia. Age-matched normal control temporal bones were also selected. The vestibular hair cells including types I and II hair cells were counted separately in the saccular macula, utricular macula, and three cristae of the semicircular canals using Nomarski microscopy. Results: The hair cell densities of types I and II hair cells in the macula of the saccule in cochleosaccular dysplasia were significantly decreased compared with the data of normal subjects. Both types I and II hair cells in the utricular macula and the cristae of the three semicircular canals in cochleosaccular dysplasia were well preserved, and no significant difference was observed between findings of cochleosaccular dysplasia and normal controls in the utricle and the three semicircular canals. Conclusions: In cases with cochleosaccular dysplasia, the neurosensorial hair cells of the saccule were affected; however, the osseous labyrinth, the membranous utricle, and the semi-circular canals were normal. Further studies should be performed to establish the pathogenesis of cochleosaccular dysplasia in humans.",
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AU - Paparella, Michael M.

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N2 - Background: Cochleosaccular dysplasia is the most common pathologic finding seen in children with profound congenital sensorineural hearing loss. There has been no quantitative study on the peripheral vestibular system in cochleosaccular dysplasia. Objective: To investigate quantitatively the extent of pathologic changes of the vestibular sensory epithelium in cochleosaccular dysplasia. Subjects and Methods: Thirteen temporal bones with congenital deafness from 10 individuals were selected for this study from the temporal bone collection of University of Minnesota that showed suitable pathologic findings for the histopathologic criteria of cochleosaccular dysplasia. Age-matched normal control temporal bones were also selected. The vestibular hair cells including types I and II hair cells were counted separately in the saccular macula, utricular macula, and three cristae of the semicircular canals using Nomarski microscopy. Results: The hair cell densities of types I and II hair cells in the macula of the saccule in cochleosaccular dysplasia were significantly decreased compared with the data of normal subjects. Both types I and II hair cells in the utricular macula and the cristae of the three semicircular canals in cochleosaccular dysplasia were well preserved, and no significant difference was observed between findings of cochleosaccular dysplasia and normal controls in the utricle and the three semicircular canals. Conclusions: In cases with cochleosaccular dysplasia, the neurosensorial hair cells of the saccule were affected; however, the osseous labyrinth, the membranous utricle, and the semi-circular canals were normal. Further studies should be performed to establish the pathogenesis of cochleosaccular dysplasia in humans.

AB - Background: Cochleosaccular dysplasia is the most common pathologic finding seen in children with profound congenital sensorineural hearing loss. There has been no quantitative study on the peripheral vestibular system in cochleosaccular dysplasia. Objective: To investigate quantitatively the extent of pathologic changes of the vestibular sensory epithelium in cochleosaccular dysplasia. Subjects and Methods: Thirteen temporal bones with congenital deafness from 10 individuals were selected for this study from the temporal bone collection of University of Minnesota that showed suitable pathologic findings for the histopathologic criteria of cochleosaccular dysplasia. Age-matched normal control temporal bones were also selected. The vestibular hair cells including types I and II hair cells were counted separately in the saccular macula, utricular macula, and three cristae of the semicircular canals using Nomarski microscopy. Results: The hair cell densities of types I and II hair cells in the macula of the saccule in cochleosaccular dysplasia were significantly decreased compared with the data of normal subjects. Both types I and II hair cells in the utricular macula and the cristae of the three semicircular canals in cochleosaccular dysplasia were well preserved, and no significant difference was observed between findings of cochleosaccular dysplasia and normal controls in the utricle and the three semicircular canals. Conclusions: In cases with cochleosaccular dysplasia, the neurosensorial hair cells of the saccule were affected; however, the osseous labyrinth, the membranous utricle, and the semi-circular canals were normal. Further studies should be performed to establish the pathogenesis of cochleosaccular dysplasia in humans.

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KW - Scheibe's dysplasia

KW - Semicircular canal

KW - Utricle

KW - Vestibule

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