Quantitative evaluation of the neuroprotective effects of thiopental sodium, propofol, and halothane on brain ischemia in the gerbil: Effects of the anesthetics on ischemic depolarization and extracellular glutamate concentration

Motomu Kobayashi, Yoshimasa Takeda, Hideki Taninishi, Ken Takata, Hisami Aoe, Kiyoshi Morita

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Although propofol and thiopental are commonly used as neuroprotective agents, it has not been determined which is more neuroprotective. This study was designed to quantitatively evaluate the neuroprotective effects of thiopental, propofol, and halothane on brain ischemia by determining P50, ischemic time necessary for causing 50% neuronal damage. Gerbils were anesthetized with thiopental, propofol, or halothane and underwent 2-vessel occlusion (0, 3, 5 or 10 min). Direct current potentials were measured in bilateral CA1 regions, in which histologic evaluation was performed 5 days later. In some animals, extracellular glutamate concentrations (microdialysis) were measured during 7.5 minutes of ischemia. P50 in the thiopental, propofol, and halothane groups were estimated to be 8.4, 6.5 (P

Original languageEnglish
Pages (from-to)171-178
Number of pages8
JournalJournal of Neurosurgical Anesthesiology
Volume19
Issue number3
DOIs
Publication statusPublished - Jul 2007

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Thiopental
Gerbillinae
Neuroprotective Agents
Propofol
Halothane
Brain Ischemia
Anesthetics
Glutamic Acid
Microdialysis
Ischemia

Keywords

  • Anesthetics
  • Brain ischemia
  • Extracellular glutamate concentration
  • Ischemic depolarization
  • Neuroprotective effect

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Clinical Neurology

Cite this

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AU - Takeda, Yoshimasa

AU - Taninishi, Hideki

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AU - Aoe, Hisami

AU - Morita, Kiyoshi

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