Quantitative evaluation of the neuroprotective effects of a short-acting β-adrenoceptor antagonist at a clinical dose on forebrain ischemia in gerbils: Effects of esmolol on ischemic depolarization and histologic outcome of hippocampal CA1

Tetsuya Danura, Yoshimasa Takeda, Kensuke Shiraishi, Hiromichi Naito, Ryoichi Mizoue, Sachiko Sato, Kiyoshi Morita

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Neuroprotective effects of esmolol in laboratory and clinical settings have been reported. The present study was designed to quantitatively evaluate the neuroprotective effects of esmolol using logistic regression curves and extracellular potentials. Materials and Methods: In 42 gerbils, bilateral occlusion of common carotid arteries was performed for 3, 5, or 7 minutes (n=7 in each group). In treated animals, esmolol (200 μg/kg/min) was administered for 90 minutes, 30 minutes before the onset of ischemia. Direct current potentials were measured in the bilateral CA1 regions, in which histologic evaluation was performed 5 days later. Relations of neuronal damage with ischemic duration and duration of ischemic depolarization were determined using logistic regression curves. Results: There was no significant difference in onset time between the 2 groups (the control group vs. The esmolol group: 1.65±0.46 vs. 1.68±0.45 min, P=0.76), and significant differences in durations of ischemic depolarization were not observed with any ischemic duration. However, logistic regression curves indicated that esmolol has a neuroprotective effect from 2.95 to 7.66 minutes of ischemic depolarization (P<0.05), and esmolol prolonged the duration of ischemic depolarization causing 50% neuronal damage from 4.97 to 6.34 minutes (P<0.05). Logistic regression curves also indicated that esmolol has a neuroprotective effect from 3.77 to 7.74 minutes of ischemic duration (P<0.05), and esmolol prolonged the ischemic duration causing 50% neuronal damage from 4.26 to 4.91 minutes (P<0.05). Conclusions: Esmolol has neuroprotective effects in the acute phase of ischemia by a mechanism other than shortening the duration of ischemic depolarization.

Original languageEnglish
Pages (from-to)292-298
Number of pages7
JournalJournal of Neurosurgical Anesthesiology
Volume25
Issue number3
DOIs
Publication statusPublished - Jul 1 2013

Keywords

  • Esmolol
  • brain ischemia
  • ischemic depolarization
  • neuroprotective effect
  • β-adrenoceptor

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Fingerprint Dive into the research topics of 'Quantitative evaluation of the neuroprotective effects of a short-acting β-adrenoceptor antagonist at a clinical dose on forebrain ischemia in gerbils: Effects of esmolol on ischemic depolarization and histologic outcome of hippocampal CA1'. Together they form a unique fingerprint.

  • Cite this