Abstract
Background: Neuroprotective effects of esmolol in laboratory and clinical settings have been reported. The present study was designed to quantitatively evaluate the neuroprotective effects of esmolol using logistic regression curves and extracellular potentials. Materials and Methods: In 42 gerbils, bilateral occlusion of common carotid arteries was performed for 3, 5, or 7 minutes (n=7 in each group). In treated animals, esmolol (200 μg/kg/min) was administered for 90 minutes, 30 minutes before the onset of ischemia. Direct current potentials were measured in the bilateral CA1 regions, in which histologic evaluation was performed 5 days later. Relations of neuronal damage with ischemic duration and duration of ischemic depolarization were determined using logistic regression curves. Results: There was no significant difference in onset time between the 2 groups (the control group vs. The esmolol group: 1.65±0.46 vs. 1.68±0.45 min, P=0.76), and significant differences in durations of ischemic depolarization were not observed with any ischemic duration. However, logistic regression curves indicated that esmolol has a neuroprotective effect from 2.95 to 7.66 minutes of ischemic depolarization (P
| Original language | English |
|---|---|
| Pages (from-to) | 292-298 |
| Number of pages | 7 |
| Journal | Journal of Neurosurgical Anesthesiology |
| Volume | 25 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jul 2013 |
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Keywords
- β-adrenoceptor
- brain ischemia
- Esmolol
- ischemic depolarization
- neuroprotective effect
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine
- Clinical Neurology
- Surgery
Cite this
Quantitative evaluation of the neuroprotective effects of a short-acting β-adrenoceptor antagonist at a clinical dose on forebrain ischemia in gerbils : Effects of esmolol on ischemic depolarization and histologic outcome of hippocampal CA1. / Danura, Tetsuya; Takeda, Yoshimasa; Shiraishi, Kensuke; Naito, Hiromichi; Mizoue, Ryoichi; Sato, Sachiko; Morita, Kiyoshi.
In: Journal of Neurosurgical Anesthesiology, Vol. 25, No. 3, 07.2013, p. 292-298.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Quantitative evaluation of the neuroprotective effects of a short-acting β-adrenoceptor antagonist at a clinical dose on forebrain ischemia in gerbils
T2 - Effects of esmolol on ischemic depolarization and histologic outcome of hippocampal CA1
AU - Danura, Tetsuya
AU - Takeda, Yoshimasa
AU - Shiraishi, Kensuke
AU - Naito, Hiromichi
AU - Mizoue, Ryoichi
AU - Sato, Sachiko
AU - Morita, Kiyoshi
PY - 2013/7
Y1 - 2013/7
N2 - Background: Neuroprotective effects of esmolol in laboratory and clinical settings have been reported. The present study was designed to quantitatively evaluate the neuroprotective effects of esmolol using logistic regression curves and extracellular potentials. Materials and Methods: In 42 gerbils, bilateral occlusion of common carotid arteries was performed for 3, 5, or 7 minutes (n=7 in each group). In treated animals, esmolol (200 μg/kg/min) was administered for 90 minutes, 30 minutes before the onset of ischemia. Direct current potentials were measured in the bilateral CA1 regions, in which histologic evaluation was performed 5 days later. Relations of neuronal damage with ischemic duration and duration of ischemic depolarization were determined using logistic regression curves. Results: There was no significant difference in onset time between the 2 groups (the control group vs. The esmolol group: 1.65±0.46 vs. 1.68±0.45 min, P=0.76), and significant differences in durations of ischemic depolarization were not observed with any ischemic duration. However, logistic regression curves indicated that esmolol has a neuroprotective effect from 2.95 to 7.66 minutes of ischemic depolarization (P
AB - Background: Neuroprotective effects of esmolol in laboratory and clinical settings have been reported. The present study was designed to quantitatively evaluate the neuroprotective effects of esmolol using logistic regression curves and extracellular potentials. Materials and Methods: In 42 gerbils, bilateral occlusion of common carotid arteries was performed for 3, 5, or 7 minutes (n=7 in each group). In treated animals, esmolol (200 μg/kg/min) was administered for 90 minutes, 30 minutes before the onset of ischemia. Direct current potentials were measured in the bilateral CA1 regions, in which histologic evaluation was performed 5 days later. Relations of neuronal damage with ischemic duration and duration of ischemic depolarization were determined using logistic regression curves. Results: There was no significant difference in onset time between the 2 groups (the control group vs. The esmolol group: 1.65±0.46 vs. 1.68±0.45 min, P=0.76), and significant differences in durations of ischemic depolarization were not observed with any ischemic duration. However, logistic regression curves indicated that esmolol has a neuroprotective effect from 2.95 to 7.66 minutes of ischemic depolarization (P
KW - β-adrenoceptor
KW - brain ischemia
KW - Esmolol
KW - ischemic depolarization
KW - neuroprotective effect
UR - http://www.scopus.com/inward/record.url?scp=84880045697&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84880045697&partnerID=8YFLogxK
U2 - 10.1097/ANA.0b013e31827fe3b1
DO - 10.1097/ANA.0b013e31827fe3b1
M3 - Article
VL - 25
SP - 292
EP - 298
JO - Journal of Neurosurgical Anesthesiology
JF - Journal of Neurosurgical Anesthesiology
SN - 0898-4921
IS - 3
ER -