Quantitative evaluation of the neuroprotective effects of a short-acting β-adrenoceptor antagonist at a clinical dose on forebrain ischemia in gerbils: Effects of esmolol on ischemic depolarization and histologic outcome of hippocampal CA1

Tetsuya Danura, Yoshimasa Takeda, Kensuke Shiraishi, Hiromichi Naito, Ryoichi Mizoue, Sachiko Sato, Kiyoshi Morita

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3 Citations (Scopus)

Abstract

Background: Neuroprotective effects of esmolol in laboratory and clinical settings have been reported. The present study was designed to quantitatively evaluate the neuroprotective effects of esmolol using logistic regression curves and extracellular potentials. Materials and Methods: In 42 gerbils, bilateral occlusion of common carotid arteries was performed for 3, 5, or 7 minutes (n=7 in each group). In treated animals, esmolol (200 μg/kg/min) was administered for 90 minutes, 30 minutes before the onset of ischemia. Direct current potentials were measured in the bilateral CA1 regions, in which histologic evaluation was performed 5 days later. Relations of neuronal damage with ischemic duration and duration of ischemic depolarization were determined using logistic regression curves. Results: There was no significant difference in onset time between the 2 groups (the control group vs. The esmolol group: 1.65±0.46 vs. 1.68±0.45 min, P=0.76), and significant differences in durations of ischemic depolarization were not observed with any ischemic duration. However, logistic regression curves indicated that esmolol has a neuroprotective effect from 2.95 to 7.66 minutes of ischemic depolarization (P

Original languageEnglish
Pages (from-to)292-298
Number of pages7
JournalJournal of Neurosurgical Anesthesiology
Volume25
Issue number3
DOIs
Publication statusPublished - Jul 2013

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Gerbillinae
Neuroprotective Agents
Prosencephalon
Adrenergic Receptors
Ischemia
Logistic Models
Common Carotid Artery
esmolol
Control Groups

Keywords

  • β-adrenoceptor
  • brain ischemia
  • Esmolol
  • ischemic depolarization
  • neuroprotective effect

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Clinical Neurology
  • Surgery

Cite this

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title = "Quantitative evaluation of the neuroprotective effects of a short-acting β-adrenoceptor antagonist at a clinical dose on forebrain ischemia in gerbils: Effects of esmolol on ischemic depolarization and histologic outcome of hippocampal CA1",
abstract = "Background: Neuroprotective effects of esmolol in laboratory and clinical settings have been reported. The present study was designed to quantitatively evaluate the neuroprotective effects of esmolol using logistic regression curves and extracellular potentials. Materials and Methods: In 42 gerbils, bilateral occlusion of common carotid arteries was performed for 3, 5, or 7 minutes (n=7 in each group). In treated animals, esmolol (200 μg/kg/min) was administered for 90 minutes, 30 minutes before the onset of ischemia. Direct current potentials were measured in the bilateral CA1 regions, in which histologic evaluation was performed 5 days later. Relations of neuronal damage with ischemic duration and duration of ischemic depolarization were determined using logistic regression curves. Results: There was no significant difference in onset time between the 2 groups (the control group vs. The esmolol group: 1.65±0.46 vs. 1.68±0.45 min, P=0.76), and significant differences in durations of ischemic depolarization were not observed with any ischemic duration. However, logistic regression curves indicated that esmolol has a neuroprotective effect from 2.95 to 7.66 minutes of ischemic depolarization (P",
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T1 - Quantitative evaluation of the neuroprotective effects of a short-acting β-adrenoceptor antagonist at a clinical dose on forebrain ischemia in gerbils

T2 - Effects of esmolol on ischemic depolarization and histologic outcome of hippocampal CA1

AU - Danura, Tetsuya

AU - Takeda, Yoshimasa

AU - Shiraishi, Kensuke

AU - Naito, Hiromichi

AU - Mizoue, Ryoichi

AU - Sato, Sachiko

AU - Morita, Kiyoshi

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N2 - Background: Neuroprotective effects of esmolol in laboratory and clinical settings have been reported. The present study was designed to quantitatively evaluate the neuroprotective effects of esmolol using logistic regression curves and extracellular potentials. Materials and Methods: In 42 gerbils, bilateral occlusion of common carotid arteries was performed for 3, 5, or 7 minutes (n=7 in each group). In treated animals, esmolol (200 μg/kg/min) was administered for 90 minutes, 30 minutes before the onset of ischemia. Direct current potentials were measured in the bilateral CA1 regions, in which histologic evaluation was performed 5 days later. Relations of neuronal damage with ischemic duration and duration of ischemic depolarization were determined using logistic regression curves. Results: There was no significant difference in onset time between the 2 groups (the control group vs. The esmolol group: 1.65±0.46 vs. 1.68±0.45 min, P=0.76), and significant differences in durations of ischemic depolarization were not observed with any ischemic duration. However, logistic regression curves indicated that esmolol has a neuroprotective effect from 2.95 to 7.66 minutes of ischemic depolarization (P

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