Quantitative evaluation of liver function using 99mTc-GSA in rats with liver injury induced by ischemia-reperfusion

S. Hashimura, Y. Kohno, H. Gohbara, T. Nakagawa, M. Shimizu, H. Niiya, Yoshihiro Takeda, Y. Hiraki

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We evaluated quantitatively the liver injury of rats induced by ischemia-reperfusion, using 99mTc-DTPA-Galactosyl-Human-Serum-Albumin (99mTc-GSA). The vessels of the left lobe were clamped for 5, 10, or 45 minutes followed by 15 minutes reperfusion. Then, 99mTc-GSA was intravenously administered (170 micrograms/kg body weight) to rats. Two compartment analysis was made on measurement curves in the heart and liver to obtain clearance parameters. Significant difference was observed between the ischemic group (clamped for 10 and for 45 minutes) and the control. These results suggest that 99mTc-GSA is useful in the estimation of liver injury produced by ischemia-reperfusion.

Original languageEnglish
Pages (from-to)503-504
Number of pages2
JournalNippon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica
Volume52
Issue number4
Publication statusPublished - Apr 25 1992

Fingerprint

Pentetic Acid
Reperfusion Injury
Serum Albumin
Reperfusion
Liver
Ischemia
Body Weight
Wounds and Injuries

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hashimura, S., Kohno, Y., Gohbara, H., Nakagawa, T., Shimizu, M., Niiya, H., ... Hiraki, Y. (1992). Quantitative evaluation of liver function using 99mTc-GSA in rats with liver injury induced by ischemia-reperfusion. Nippon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica, 52(4), 503-504.

Quantitative evaluation of liver function using 99mTc-GSA in rats with liver injury induced by ischemia-reperfusion. / Hashimura, S.; Kohno, Y.; Gohbara, H.; Nakagawa, T.; Shimizu, M.; Niiya, H.; Takeda, Yoshihiro; Hiraki, Y.

In: Nippon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica, Vol. 52, No. 4, 25.04.1992, p. 503-504.

Research output: Contribution to journalArticle

Hashimura, S. ; Kohno, Y. ; Gohbara, H. ; Nakagawa, T. ; Shimizu, M. ; Niiya, H. ; Takeda, Yoshihiro ; Hiraki, Y. / Quantitative evaluation of liver function using 99mTc-GSA in rats with liver injury induced by ischemia-reperfusion. In: Nippon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica. 1992 ; Vol. 52, No. 4. pp. 503-504.
@article{3ea90a60f2604d709f6e750cdb1b8e75,
title = "Quantitative evaluation of liver function using 99mTc-GSA in rats with liver injury induced by ischemia-reperfusion",
abstract = "We evaluated quantitatively the liver injury of rats induced by ischemia-reperfusion, using 99mTc-DTPA-Galactosyl-Human-Serum-Albumin (99mTc-GSA). The vessels of the left lobe were clamped for 5, 10, or 45 minutes followed by 15 minutes reperfusion. Then, 99mTc-GSA was intravenously administered (170 micrograms/kg body weight) to rats. Two compartment analysis was made on measurement curves in the heart and liver to obtain clearance parameters. Significant difference was observed between the ischemic group (clamped for 10 and for 45 minutes) and the control. These results suggest that 99mTc-GSA is useful in the estimation of liver injury produced by ischemia-reperfusion.",
author = "S. Hashimura and Y. Kohno and H. Gohbara and T. Nakagawa and M. Shimizu and H. Niiya and Yoshihiro Takeda and Y. Hiraki",
year = "1992",
month = "4",
day = "25",
language = "English",
volume = "52",
pages = "503--504",
journal = "Nippon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica",
issn = "0048-0428",
publisher = "Japan Radiological Society",
number = "4",

}

TY - JOUR

T1 - Quantitative evaluation of liver function using 99mTc-GSA in rats with liver injury induced by ischemia-reperfusion

AU - Hashimura, S.

AU - Kohno, Y.

AU - Gohbara, H.

AU - Nakagawa, T.

AU - Shimizu, M.

AU - Niiya, H.

AU - Takeda, Yoshihiro

AU - Hiraki, Y.

PY - 1992/4/25

Y1 - 1992/4/25

N2 - We evaluated quantitatively the liver injury of rats induced by ischemia-reperfusion, using 99mTc-DTPA-Galactosyl-Human-Serum-Albumin (99mTc-GSA). The vessels of the left lobe were clamped for 5, 10, or 45 minutes followed by 15 minutes reperfusion. Then, 99mTc-GSA was intravenously administered (170 micrograms/kg body weight) to rats. Two compartment analysis was made on measurement curves in the heart and liver to obtain clearance parameters. Significant difference was observed between the ischemic group (clamped for 10 and for 45 minutes) and the control. These results suggest that 99mTc-GSA is useful in the estimation of liver injury produced by ischemia-reperfusion.

AB - We evaluated quantitatively the liver injury of rats induced by ischemia-reperfusion, using 99mTc-DTPA-Galactosyl-Human-Serum-Albumin (99mTc-GSA). The vessels of the left lobe were clamped for 5, 10, or 45 minutes followed by 15 minutes reperfusion. Then, 99mTc-GSA was intravenously administered (170 micrograms/kg body weight) to rats. Two compartment analysis was made on measurement curves in the heart and liver to obtain clearance parameters. Significant difference was observed between the ischemic group (clamped for 10 and for 45 minutes) and the control. These results suggest that 99mTc-GSA is useful in the estimation of liver injury produced by ischemia-reperfusion.

UR - http://www.scopus.com/inward/record.url?scp=0027126762&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027126762&partnerID=8YFLogxK

M3 - Article

VL - 52

SP - 503

EP - 504

JO - Nippon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica

JF - Nippon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica

SN - 0048-0428

IS - 4

ER -