Quantitative evaluation of liver function using 99mTc-GSA in rats with liver injury induced by ischemia-reperfusion

S. Hashimura, Y. Kohno, H. Gohbara, T. Nakagawa, M. Shimizu, H. Niiya, Yoshihiro Takeda, Y. Hiraki

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Abstract

We evaluated quantitatively the liver injury of rats induced by ischemia-reperfusion, using 99mTc-DTPA-Galactosyl-Human-Serum-Albumin (99mTc-GSA). The vessels of the left lobe were clamped for 5, 10, or 45 minutes followed by 15 minutes reperfusion. Then, 99mTc-GSA was intravenously administered (170 micrograms/kg body weight) to rats. Two compartment analysis was made on measurement curves in the heart and liver to obtain clearance parameters. Significant difference was observed between the ischemic group (clamped for 10 and for 45 minutes) and the control. These results suggest that 99mTc-GSA is useful in the estimation of liver injury produced by ischemia-reperfusion.

Original languageEnglish
Pages (from-to)503-504
Number of pages2
JournalNippon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica
Volume52
Issue number4
Publication statusPublished - Apr 25 1992

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ASJC Scopus subject areas

  • Medicine(all)

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