Quantification of L-type fatty acid binding protein in the urine of preterm neonates

Hirokazu Tsukahara, Takeshi Sugaya, Kazuyo Hayakawa, Yukiko Mori, Masahiro Hiraoka, Atsuko Hata, Mitsufumi Mayumi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We measured urinary excretion of L-type fatty acid binding protein (L-FABP) in preterm neonates on days 1, 5-10, and 25-30 of life. Urinary L-FABP levels (expressed as the ratio to creatinine) in preterm neonates were considerably higher than those of healthy adults. They did not change significantly during the study period. Urinary L-FABP levels showed significant positive correlation with those of urinary N-acetyl-beta-d-glucosaminidase activity on day 1, and with those of 8-hydroxy-2′-deoxyguanosine on days 25-30. These results suggest that L-FABP is expressed in the neonatal kidney. Our results may also point to potential effects of proximal tubular damage and oxidative stress on urinary excretion of L-FABP.

Original languageEnglish
Pages (from-to)643-646
Number of pages4
JournalEarly Human Development
Volume81
Issue number7
DOIs
Publication statusPublished - Jul 2005
Externally publishedYes

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Fatty Acid-Binding Proteins
Urine
Newborn Infant
Hexosaminidases
Creatinine
Oxidative Stress
Kidney

Keywords

  • L-type fatty acid binding protein
  • Oxidative stress
  • Preterm neonate
  • Urine

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Quantification of L-type fatty acid binding protein in the urine of preterm neonates. / Tsukahara, Hirokazu; Sugaya, Takeshi; Hayakawa, Kazuyo; Mori, Yukiko; Hiraoka, Masahiro; Hata, Atsuko; Mayumi, Mitsufumi.

In: Early Human Development, Vol. 81, No. 7, 07.2005, p. 643-646.

Research output: Contribution to journalArticle

Tsukahara, Hirokazu ; Sugaya, Takeshi ; Hayakawa, Kazuyo ; Mori, Yukiko ; Hiraoka, Masahiro ; Hata, Atsuko ; Mayumi, Mitsufumi. / Quantification of L-type fatty acid binding protein in the urine of preterm neonates. In: Early Human Development. 2005 ; Vol. 81, No. 7. pp. 643-646.
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