Quantification of L-type fatty acid binding protein in the urine of preterm neonates

Hirokazu Tsukahara, Takeshi Sugaya, Kazuyo Hayakawa, Yukiko Mori, Masahiro Hiraoka, Atsuko Hata, Mitsufumi Mayumi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We measured urinary excretion of L-type fatty acid binding protein (L-FABP) in preterm neonates on days 1, 5-10, and 25-30 of life. Urinary L-FABP levels (expressed as the ratio to creatinine) in preterm neonates were considerably higher than those of healthy adults. They did not change significantly during the study period. Urinary L-FABP levels showed significant positive correlation with those of urinary N-acetyl-beta-d-glucosaminidase activity on day 1, and with those of 8-hydroxy-2′-deoxyguanosine on days 25-30. These results suggest that L-FABP is expressed in the neonatal kidney. Our results may also point to potential effects of proximal tubular damage and oxidative stress on urinary excretion of L-FABP.

Original languageEnglish
Pages (from-to)643-646
Number of pages4
JournalEarly Human Development
Volume81
Issue number7
DOIs
Publication statusPublished - Jul 2005
Externally publishedYes

Keywords

  • L-type fatty acid binding protein
  • Oxidative stress
  • Preterm neonate
  • Urine

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

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