Quality of life of survivors of malignant pleural mesothelioma in Japan: A cross sectional study

Yasuko Nagamatsu, Isao Oze, Keisuke Aoe, Katsuyuki Hotta, Katsuya Kato, Junko Nakagawa, Keiko Hara, Takumi Kishimoto, Nobukazu Fujimoto

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Previous studies have indicated that people with malignant pleural mesothelioma (MPM) have a poor quality of life (QOL); however, information about the QOL of people with MPM in Japan is anecdotal. The aims of this study were to investigate the QOL of survivors of MPM in Japan and to determine the factors that correlate with their QOL. Methods: This was a cross sectional study. The included patients were those diagnosed with MPM in Japan. We created a self-administered questionnaire consisting of 64 questions. The questionnaires were sent to hospitals and patient advocacy groups, distributed to the patients, completed, and sent back to the researchers by postal mail. QOL was assessed with the European Organization for Research and Treatment of Cancer 16 questionnaire (QLQ) and the short version of the core domains of the Comprehensive Quality of Life Outcome questionnaire (CoQoLo). Results: In total, 133 questionnaires were collected. The QLQ assessments demonstrated that the survivors of MPM most frequently complained of fatigue, pain, sleep disturbances, and dyspnea. The symptom scales were acceptable, but the functional scales were significantly poorer for the patients with poor performance statuses (PSs). The short CoQoLo assessment was very unfavorable for 'Being free from physical pain.' Being a long-term survivor and a survivor with a poor PS were significantly correlated with poor global health status. Conclusions: Survivors of MPM have impaired function, a variety of symptoms, and lower QOL. Survivors of MPM, even those in good physical condition, need broad support.

Original languageEnglish
Article number350
JournalBMC Cancer
Volume18
Issue number1
DOIs
Publication statusPublished - Mar 27 2018

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Survivors
Japan
Cross-Sectional Studies
Quality of Life
Patient Advocacy
Malignant Mesothelioma
Postal Service
Dyspnea
Health Status
Fatigue
Surveys and Questionnaires
Sleep
Research Personnel
Outcome Assessment (Health Care)
Organizations
Pain
Research
Neoplasms

Keywords

  • Asbestos
  • CoQoLo
  • Mesothelioma
  • Palliative care
  • Quality of life
  • Questionnaire

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

Cite this

Quality of life of survivors of malignant pleural mesothelioma in Japan : A cross sectional study. / Nagamatsu, Yasuko; Oze, Isao; Aoe, Keisuke; Hotta, Katsuyuki; Kato, Katsuya; Nakagawa, Junko; Hara, Keiko; Kishimoto, Takumi; Fujimoto, Nobukazu.

In: BMC Cancer, Vol. 18, No. 1, 350, 27.03.2018.

Research output: Contribution to journalArticle

Nagamatsu, Y, Oze, I, Aoe, K, Hotta, K, Kato, K, Nakagawa, J, Hara, K, Kishimoto, T & Fujimoto, N 2018, 'Quality of life of survivors of malignant pleural mesothelioma in Japan: A cross sectional study', BMC Cancer, vol. 18, no. 1, 350. https://doi.org/10.1186/s12885-018-4293-x
Nagamatsu, Yasuko ; Oze, Isao ; Aoe, Keisuke ; Hotta, Katsuyuki ; Kato, Katsuya ; Nakagawa, Junko ; Hara, Keiko ; Kishimoto, Takumi ; Fujimoto, Nobukazu. / Quality of life of survivors of malignant pleural mesothelioma in Japan : A cross sectional study. In: BMC Cancer. 2018 ; Vol. 18, No. 1.
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AU - Nagamatsu, Yasuko

AU - Oze, Isao

AU - Aoe, Keisuke

AU - Hotta, Katsuyuki

AU - Kato, Katsuya

AU - Nakagawa, Junko

AU - Hara, Keiko

AU - Kishimoto, Takumi

AU - Fujimoto, Nobukazu

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N2 - Background: Previous studies have indicated that people with malignant pleural mesothelioma (MPM) have a poor quality of life (QOL); however, information about the QOL of people with MPM in Japan is anecdotal. The aims of this study were to investigate the QOL of survivors of MPM in Japan and to determine the factors that correlate with their QOL. Methods: This was a cross sectional study. The included patients were those diagnosed with MPM in Japan. We created a self-administered questionnaire consisting of 64 questions. The questionnaires were sent to hospitals and patient advocacy groups, distributed to the patients, completed, and sent back to the researchers by postal mail. QOL was assessed with the European Organization for Research and Treatment of Cancer 16 questionnaire (QLQ) and the short version of the core domains of the Comprehensive Quality of Life Outcome questionnaire (CoQoLo). Results: In total, 133 questionnaires were collected. The QLQ assessments demonstrated that the survivors of MPM most frequently complained of fatigue, pain, sleep disturbances, and dyspnea. The symptom scales were acceptable, but the functional scales were significantly poorer for the patients with poor performance statuses (PSs). The short CoQoLo assessment was very unfavorable for 'Being free from physical pain.' Being a long-term survivor and a survivor with a poor PS were significantly correlated with poor global health status. Conclusions: Survivors of MPM have impaired function, a variety of symptoms, and lower QOL. Survivors of MPM, even those in good physical condition, need broad support.

AB - Background: Previous studies have indicated that people with malignant pleural mesothelioma (MPM) have a poor quality of life (QOL); however, information about the QOL of people with MPM in Japan is anecdotal. The aims of this study were to investigate the QOL of survivors of MPM in Japan and to determine the factors that correlate with their QOL. Methods: This was a cross sectional study. The included patients were those diagnosed with MPM in Japan. We created a self-administered questionnaire consisting of 64 questions. The questionnaires were sent to hospitals and patient advocacy groups, distributed to the patients, completed, and sent back to the researchers by postal mail. QOL was assessed with the European Organization for Research and Treatment of Cancer 16 questionnaire (QLQ) and the short version of the core domains of the Comprehensive Quality of Life Outcome questionnaire (CoQoLo). Results: In total, 133 questionnaires were collected. The QLQ assessments demonstrated that the survivors of MPM most frequently complained of fatigue, pain, sleep disturbances, and dyspnea. The symptom scales were acceptable, but the functional scales were significantly poorer for the patients with poor performance statuses (PSs). The short CoQoLo assessment was very unfavorable for 'Being free from physical pain.' Being a long-term survivor and a survivor with a poor PS were significantly correlated with poor global health status. Conclusions: Survivors of MPM have impaired function, a variety of symptoms, and lower QOL. Survivors of MPM, even those in good physical condition, need broad support.

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