Quality evaluation of radiographic contrast media in large-volume prefilled syringes and vials

Toshiaki Sendo, M. Hirakawa, M. Yaginuma, T. Aoyama, R. Oishi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Rationale and Objectives. The authors compared the particle contaminations of radiographic contrast media packaged in large-volume prefilled syringes and vials. Materials and Methods. Particle counting was performed for four contrast media packaged in large-volume prefilled syringes (iohexol, ioversol, ioversol for angiography, and ioxaglate) and three contrast media packaged in vials (iohexol, ioversol, and ioxaglate). X-ray emission spectrometry was performed to characterize the individual particles. The amount of silicone oil in the syringe was quantified with infrared spectrophotometry. Results. The particle contamination in syringes containing ioversol was higher than that in syringes containing iohexol or ioxaglate. Particle contamination in the vials was relatively low, except with ioxaglate. X-ray emission spectrometry of the components of the syringe and vial showed that the source of particles was internal material released from the rubber stopper or inner surface. Conclusion. The particle counts for contrast media packaged in syringes and vials varied considerably among the different contrast media and were related to the amount of silicone oil in the inner surface and rubber piston of the syringe.

Original languageEnglish
Pages (from-to)444-447
Number of pages4
JournalAcademic Radiology
Volume5
Issue number6
DOIs
Publication statusPublished - 1998
Externally publishedYes

Fingerprint

ioversol
Syringes
Contrast Media
Ioxaglic Acid
Iohexol
X-Ray Emission Spectrometry
Silicone Oils
Rubber
Infrared Spectrophotometry
Prefil
Angiography

Keywords

  • Contrast media
  • Iohexol
  • Ioversol
  • Ioxaglate
  • Quality assurance

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Quality evaluation of radiographic contrast media in large-volume prefilled syringes and vials. / Sendo, Toshiaki; Hirakawa, M.; Yaginuma, M.; Aoyama, T.; Oishi, R.

In: Academic Radiology, Vol. 5, No. 6, 1998, p. 444-447.

Research output: Contribution to journalArticle

Sendo, Toshiaki ; Hirakawa, M. ; Yaginuma, M. ; Aoyama, T. ; Oishi, R. / Quality evaluation of radiographic contrast media in large-volume prefilled syringes and vials. In: Academic Radiology. 1998 ; Vol. 5, No. 6. pp. 444-447.
@article{24c5408ec49a4e43aa67ddd317256910,
title = "Quality evaluation of radiographic contrast media in large-volume prefilled syringes and vials",
abstract = "Rationale and Objectives. The authors compared the particle contaminations of radiographic contrast media packaged in large-volume prefilled syringes and vials. Materials and Methods. Particle counting was performed for four contrast media packaged in large-volume prefilled syringes (iohexol, ioversol, ioversol for angiography, and ioxaglate) and three contrast media packaged in vials (iohexol, ioversol, and ioxaglate). X-ray emission spectrometry was performed to characterize the individual particles. The amount of silicone oil in the syringe was quantified with infrared spectrophotometry. Results. The particle contamination in syringes containing ioversol was higher than that in syringes containing iohexol or ioxaglate. Particle contamination in the vials was relatively low, except with ioxaglate. X-ray emission spectrometry of the components of the syringe and vial showed that the source of particles was internal material released from the rubber stopper or inner surface. Conclusion. The particle counts for contrast media packaged in syringes and vials varied considerably among the different contrast media and were related to the amount of silicone oil in the inner surface and rubber piston of the syringe.",
keywords = "Contrast media, Iohexol, Ioversol, Ioxaglate, Quality assurance",
author = "Toshiaki Sendo and M. Hirakawa and M. Yaginuma and T. Aoyama and R. Oishi",
year = "1998",
doi = "10.1016/S1076-6332(98)80032-9",
language = "English",
volume = "5",
pages = "444--447",
journal = "Academic Radiology",
issn = "1076-6332",
publisher = "Elsevier USA",
number = "6",

}

TY - JOUR

T1 - Quality evaluation of radiographic contrast media in large-volume prefilled syringes and vials

AU - Sendo, Toshiaki

AU - Hirakawa, M.

AU - Yaginuma, M.

AU - Aoyama, T.

AU - Oishi, R.

PY - 1998

Y1 - 1998

N2 - Rationale and Objectives. The authors compared the particle contaminations of radiographic contrast media packaged in large-volume prefilled syringes and vials. Materials and Methods. Particle counting was performed for four contrast media packaged in large-volume prefilled syringes (iohexol, ioversol, ioversol for angiography, and ioxaglate) and three contrast media packaged in vials (iohexol, ioversol, and ioxaglate). X-ray emission spectrometry was performed to characterize the individual particles. The amount of silicone oil in the syringe was quantified with infrared spectrophotometry. Results. The particle contamination in syringes containing ioversol was higher than that in syringes containing iohexol or ioxaglate. Particle contamination in the vials was relatively low, except with ioxaglate. X-ray emission spectrometry of the components of the syringe and vial showed that the source of particles was internal material released from the rubber stopper or inner surface. Conclusion. The particle counts for contrast media packaged in syringes and vials varied considerably among the different contrast media and were related to the amount of silicone oil in the inner surface and rubber piston of the syringe.

AB - Rationale and Objectives. The authors compared the particle contaminations of radiographic contrast media packaged in large-volume prefilled syringes and vials. Materials and Methods. Particle counting was performed for four contrast media packaged in large-volume prefilled syringes (iohexol, ioversol, ioversol for angiography, and ioxaglate) and three contrast media packaged in vials (iohexol, ioversol, and ioxaglate). X-ray emission spectrometry was performed to characterize the individual particles. The amount of silicone oil in the syringe was quantified with infrared spectrophotometry. Results. The particle contamination in syringes containing ioversol was higher than that in syringes containing iohexol or ioxaglate. Particle contamination in the vials was relatively low, except with ioxaglate. X-ray emission spectrometry of the components of the syringe and vial showed that the source of particles was internal material released from the rubber stopper or inner surface. Conclusion. The particle counts for contrast media packaged in syringes and vials varied considerably among the different contrast media and were related to the amount of silicone oil in the inner surface and rubber piston of the syringe.

KW - Contrast media

KW - Iohexol

KW - Ioversol

KW - Ioxaglate

KW - Quality assurance

UR - http://www.scopus.com/inward/record.url?scp=0031814770&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031814770&partnerID=8YFLogxK

U2 - 10.1016/S1076-6332(98)80032-9

DO - 10.1016/S1076-6332(98)80032-9

M3 - Article

C2 - 9615155

AN - SCOPUS:0031814770

VL - 5

SP - 444

EP - 447

JO - Academic Radiology

JF - Academic Radiology

SN - 1076-6332

IS - 6

ER -