Qualitative investigation of the factors that generate ambivalent feelings in women who give birth after receiving negative results from non-invasive prenatal testing

Junko Yotsumoto, Akihiko Sekizawa, Satomi Inoue, Nobuhiro Suzumori, Osamu Samura, Takahiro Yamada, Kiyonori Miura, Hideaki Masuzaki, Hideaki Sawai, Jun Murotsuki, Haruka Hamanoue, Yoshimasa Kamei, Toshiaki Endo, Akimune Fukushima, Yukiko Katagiri, Naoki Takeshita, Masaki Ogawa, Haruki Nishizawa, Yoko Okamoto, Shinya TairakuTakashi Kaji, Kazuhisa Maeda, Keiichi Matsubara, Masanobu Ogawa, Hisao Osada, Takashi Ohba, Yukie Kawano, Aiko Sasaki, Haruhiko Sago, Seiji Wada, Miyuki Nishiyama, Akira Namba, Hisao Osada, Yasuyo Kasai, Atsushi Watanabe, Kazufumi Haino, Naoki Hamajima, Takeshi Kanagawa, Hiroaki Nakamura, Jun Yoshimatsu, Katsuhiko Naruse, Hisashi Masuyama, Maki Hyodo, Rina Akaishi, Takashi Kojima, Yuka Shibata, Nahoko Shirato, Keiko Miyagami, Tatsuko Hirose, Atsuko Saito, Yuri Hasegawa, Shoko Miura, Noriko Sasaki, Mako Ueda, Mariko Ushioda, Chiho Okada, Hiroyuki Tanaka, Mina Morii-Kashima, Kyoko Kumagai, Eri Takeda, Kumiko Oseto, Wakana Abe, Kimiko Enomoto, Yoshinobu Sugo, Mari Shinoda, Kitagawa Michihiro

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background: Women who receive negative results from non-invasive prenatal genetic testing (NIPT) may find that they later have mixed or ambivalent feelings, for example, feelings of accepting NIPT and regretting undergoing the test. This study aimed to investigate the factors generating ambivalent feelings among women who gave birth after having received negative results from NIPT. Methods: A questionnaire was sent to women who received a negative NIPT result, and a contents analysis was conducted focusing on ambivalent expressions for those 1562 women who responded the questionnaire. The qualitative data gathered from the questionnaire were analyzed using the N-Vivo software package. Results: Environmental factors, genetic counseling-related factors, and increased anticipatory anxiety, affected the feeling of ambivalence among pregnant women. Furthermore, pregnant women desired more information regarding the detailed prognosis for individuals with Down syndrome and living with them and/or termination, assuming the possibility that they were positive. Conclusions: Three major interrelated factors affected the feeling of ambivalence in women. Highlighting and discussing such factors during genetic counseling may resolve some of these ambivalences, thereby enhancing the quality of decisions made by pregnant women.

Original languageEnglish
Article number112
JournalBMC Pregnancy and Childbirth
Volume20
Issue number1
DOIs
Publication statusPublished - Feb 17 2020

Keywords

  • Ambivalence
  • Anticipatory anxiety
  • Content analysis
  • Genetic counseling
  • NIPT

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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