Pyrinodemins G-I, new bis-3-alkylpyridine alkaloids from a marine sponge Amphimedon sp.

Takaaki Kubota, Ken'Ichi Kura, Jane Fromont, Jun'Ichi Kobayashi

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Three new bis-3-alkylpyridine alkaloids, pyrinodemins G-I (1-3), were isolated from an Okinawan marine sponge Amphimedon sp. and the structures of 1-3 were elucidated on the basis of spectroscopic data. Pyrinodemins G-I (1-3) were novel bis-3-alkylpyridine alkaloids possessing an N-methoxy amide moiety, an α,β-unsaturated 3,5-disubstituted γ-lactone moiety, and a 2,3-di-substituted acrolein at a junction of two 3-alkylpyridines, respectively. Pyrinodemins G (1) and H (2) showed cytotoxicity against P388 murine leukemia cells.

Original languageEnglish
Pages (from-to)96-100
Number of pages5
JournalTetrahedron
Volume69
Issue number1
DOIs
Publication statusPublished - Jan 7 2013
Externally publishedYes

Keywords

  • Amphimedon sp.
  • Bis-3-alkylpyridine alkaloid
  • Cytotoxicity
  • Marine sponge
  • Pyrinodemins G-I

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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