TY - JOUR
T1 - Pyrinodemins e and F, new 3-alkylpyridine alkaloids from sponge Amphimedon sp.
AU - Kura, Ken'Ichi
AU - Kubota, Takaaki
AU - Fromont, Jane
AU - Kobayashi, Jun'Ichi
N1 - Funding Information:
We thank Mr. Z. Nagahama for his help with sponge collection and Ms. S. Oka, Center for Instrumental Analysis, Hokkaido University, for measurements of ESIMS and APCIMS. This work was supported by Grant-in-Aid for Science Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Two new 3-alkylpyridine alkaloids, pyrinodemins E (1) and F (2), were isolated from an Okinawan marine sponge Amphimedon sp. and the structures of 1 and 2 were elucidated on the basis of spectroscopic data. Pyrinodemins E (1) and F (2) were novel 3-alkylpyridine alkaloids possessing a 4-(methoxyamino) piperidinone moiety and an indol-3-glyoxylamide moiety, respectively. Pyrinodemin E (1) showed cytotoxicity against P388 and L1210 murine leukemia cells.
AB - Two new 3-alkylpyridine alkaloids, pyrinodemins E (1) and F (2), were isolated from an Okinawan marine sponge Amphimedon sp. and the structures of 1 and 2 were elucidated on the basis of spectroscopic data. Pyrinodemins E (1) and F (2) were novel 3-alkylpyridine alkaloids possessing a 4-(methoxyamino) piperidinone moiety and an indol-3-glyoxylamide moiety, respectively. Pyrinodemin E (1) showed cytotoxicity against P388 and L1210 murine leukemia cells.
KW - 3-Alkylpyridine alkaloids
KW - Amphimedon sp.
KW - Marine sponge
KW - Pyrinodemins E and F
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U2 - 10.1016/j.bmcl.2010.11.020
DO - 10.1016/j.bmcl.2010.11.020
M3 - Article
C2 - 21111621
AN - SCOPUS:78650512859
VL - 21
SP - 267
EP - 270
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 1
ER -
