Pyrinodemins e and F, new 3-alkylpyridine alkaloids from sponge Amphimedon sp.

Ken'Ichi Kura, Takaaki Kubota, Jane Fromont, Jun'Ichi Kobayashi

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Two new 3-alkylpyridine alkaloids, pyrinodemins E (1) and F (2), were isolated from an Okinawan marine sponge Amphimedon sp. and the structures of 1 and 2 were elucidated on the basis of spectroscopic data. Pyrinodemins E (1) and F (2) were novel 3-alkylpyridine alkaloids possessing a 4-(methoxyamino) piperidinone moiety and an indol-3-glyoxylamide moiety, respectively. Pyrinodemin E (1) showed cytotoxicity against P388 and L1210 murine leukemia cells.

Original languageEnglish
Pages (from-to)267-270
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume21
Issue number1
DOIs
Publication statusPublished - Jan 1 2011
Externally publishedYes

Keywords

  • 3-Alkylpyridine alkaloids
  • Amphimedon sp.
  • Marine sponge
  • Pyrinodemins E and F

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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