Pyrinodemins B - D, potent cytotoxic bis-pyridine alkaloids from marine sponge Amphimedon sp.

Keiko Hirano, Takaaki Kubota, Masashi Tsuda, Yuzuru Mikami, Jun'ichi Kobayashi

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)

Abstract

New bis-pyridine alkaloids, pyrinodemins B - D (1 - 3), have been isolated together with pyrinodemin A (4) and related 3-alkyl pyridine alkaloids 5 - 8 from the Okinawan marine sponge Amphimedon sp. and the structures were elucidated from spectroscopic data. Pyrinodemins B - D (1 - 3) showed potent cytotoxicity, while compounds 5 - 8 exhibited antimicrobial activity.

Original languageEnglish
Pages (from-to)974-977
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume48
Issue number7
DOIs
Publication statusPublished - Jul 2000
Externally publishedYes

Keywords

  • Amphimedon sp.
  • Antimicrobial activity
  • Bis-pyridine alkaloids
  • Cytotoxicity
  • Sponge

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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