Pyrinodemin A, a cytotoxic pyridine alkaloid with an isoxazolidine moiety from sponge Amphimedon sp.

Masashi Tsuda; Keiko Hirano; Takaaki Kubota; Jun'ichi Kobayashi

doi:10.1016/S0040-4039(99)00852-7

Pyrinodemin A, a cytotoxic pyridine alkaloid with an isoxazolidine moiety from sponge Amphimedon sp.

Masashi Tsuda, Keiko Hirano, Takaaki Kubota, Jun'ichi Kobayashi

Research output: Contribution to journal › Article › peer-review

60 Citations (Scopus)

Abstract

A novel cytotoxic pyridine alkaloid, pyrinodemin A (1), with a unique cis-cyclopent[c]isoxazolidine moiety has been isolated from the Okinawan marine sponge Amphimedon sp., and the structure was elucidated from 2D NMR data and EIMS fragmentation.

Original language	English
Pages (from-to)	4819-4820
Number of pages	2
Journal	Tetrahedron Letters
Volume	40
Issue number	26
DOIs	https://doi.org/10.1016/S0040-4039(99)00852-7
Publication status	Published - Jun 25 1999
Externally published	Yes

Keywords

Alkaloid
Isoxazolidine
Pyridine
Sponge

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0040-4039(99)00852-7

Cite this

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title = "Pyrinodemin A, a cytotoxic pyridine alkaloid with an isoxazolidine moiety from sponge Amphimedon sp.",

abstract = "A novel cytotoxic pyridine alkaloid, pyrinodemin A (1), with a unique cis-cyclopent[c]isoxazolidine moiety has been isolated from the Okinawan marine sponge Amphimedon sp., and the structure was elucidated from 2D NMR data and EIMS fragmentation.",

keywords = "Alkaloid, Isoxazolidine, Pyridine, Sponge",

author = "Masashi Tsuda and Keiko Hirano and Takaaki Kubota and Jun'ichi Kobayashi",

note = "Funding Information: Acknowledgments We thank Mr. Z. Nagahama for his help with sponge collection and Dr. J. Fromont, Western AustralianM useum, for identificationo f the sponge. This work was partly supported by a Grant-in-Aidf or Scientific Research from the Ministry of Education, Science, Sports, and Culture of Japan.",

year = "1999",

month = jun,

day = "25",

doi = "10.1016/S0040-4039(99)00852-7",

language = "English",

volume = "40",

pages = "4819--4820",

journal = "Tetrahedron Letters",

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publisher = "Elsevier Limited",

number = "26",

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TY - JOUR

T1 - Pyrinodemin A, a cytotoxic pyridine alkaloid with an isoxazolidine moiety from sponge Amphimedon sp.

AU - Tsuda, Masashi

AU - Hirano, Keiko

AU - Kubota, Takaaki

AU - Kobayashi, Jun'ichi

N1 - Funding Information: Acknowledgments We thank Mr. Z. Nagahama for his help with sponge collection and Dr. J. Fromont, Western AustralianM useum, for identificationo f the sponge. This work was partly supported by a Grant-in-Aidf or Scientific Research from the Ministry of Education, Science, Sports, and Culture of Japan.

PY - 1999/6/25

Y1 - 1999/6/25

N2 - A novel cytotoxic pyridine alkaloid, pyrinodemin A (1), with a unique cis-cyclopent[c]isoxazolidine moiety has been isolated from the Okinawan marine sponge Amphimedon sp., and the structure was elucidated from 2D NMR data and EIMS fragmentation.

AB - A novel cytotoxic pyridine alkaloid, pyrinodemin A (1), with a unique cis-cyclopent[c]isoxazolidine moiety has been isolated from the Okinawan marine sponge Amphimedon sp., and the structure was elucidated from 2D NMR data and EIMS fragmentation.

KW - Alkaloid

KW - Isoxazolidine

KW - Pyridine

KW - Sponge

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U2 - 10.1016/S0040-4039(99)00852-7

DO - 10.1016/S0040-4039(99)00852-7

M3 - Article

AN - SCOPUS:0033603481

VL - 40

SP - 4819

EP - 4820

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 26

ER -

Pyrinodemin A, a cytotoxic pyridine alkaloid with an isoxazolidine moiety from sponge Amphimedon sp.

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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