Pyoderma gangrenosum associated with chronic myeloid leukemia

A 70-year-old Japanese man was diagnosed as having chronic myeloid leukemia in December 1987. The peripheral blood leukocyte count gradually increased up to 11.4 x 10⁴/μl in October 1990, and he was treated with busulfan. In July 1991, he underwent cardiac catheter examination because he had suffered from chest pain caused by angina pectoris. Seven clays later, painful indurated erythema appeared at the site of needle puncture of the right arm. The eruption extended toward the periphery and became ulcerative. A similar eruption occurred on the face without any causative factor. A biopsy specimen was taken for routine histology.