Pustulosis Vegetans

Hachiro Tagami; Keiji Iwatsuki; Shigeho Shirahama; Mizuho Yamada

doi:10.1001/archderm.1984.01650460095028

Pustulosis Vegetans

Hachiro Tagami, Keiji Iwatsuki, Shigeho Shirahama, Mizuho Yamada

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

• Sterile pustules and crusted vegetative plaques on the trunk and limbs developed in a 24-year-old man. They left cribriform scars after healing. Histologically, the lesions showed epidermal proliferation and pustulosis resembling that found in “pyoderma vegetans” and pemphigus vegetans. The lesions were effectively suppressed in two months by the topical application of methoxsalen followed by UV-A irradiation. Studies revealed that the chemotactic activity of polymorphonuclear leukocytes (PMNs) in the patient's peripheral blood was enhanced and that an extract of lesional crusty scales showed the presence of a PMN chemotactic factor. This factor had a molecular weight near 12,500 daltons similar to that reported in psoriasis scales. We speculate that tissue destruction due to complement activation, possibly induced by immune complex-mediated reactions in the dermis, provoked a process of transepithelial elimination of the inflammatory products.

Original language	English
Pages (from-to)	1355-1359
Number of pages	5
Journal	Archives of Dermatology
Volume	120
Issue number	10
DOIs	https://doi.org/10.1001/archderm.1984.01650460095028
Publication status	Published - Oct 1984

ASJC Scopus subject areas

Dermatology

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10.1001/archderm.1984.01650460095028

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title = "Pustulosis Vegetans",

abstract = "• Sterile pustules and crusted vegetative plaques on the trunk and limbs developed in a 24-year-old man. They left cribriform scars after healing. Histologically, the lesions showed epidermal proliferation and pustulosis resembling that found in “pyoderma vegetans” and pemphigus vegetans. The lesions were effectively suppressed in two months by the topical application of methoxsalen followed by UV-A irradiation. Studies revealed that the chemotactic activity of polymorphonuclear leukocytes (PMNs) in the patient's peripheral blood was enhanced and that an extract of lesional crusty scales showed the presence of a PMN chemotactic factor. This factor had a molecular weight near 12,500 daltons similar to that reported in psoriasis scales. We speculate that tissue destruction due to complement activation, possibly induced by immune complex-mediated reactions in the dermis, provoked a process of transepithelial elimination of the inflammatory products.",

author = "Hachiro Tagami and Keiji Iwatsuki and Shigeho Shirahama and Mizuho Yamada",

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T1 - Pustulosis Vegetans

AU - Tagami, Hachiro

AU - Iwatsuki, Keiji

AU - Shirahama, Shigeho

AU - Yamada, Mizuho

PY - 1984/10

Y1 - 1984/10

N2 - • Sterile pustules and crusted vegetative plaques on the trunk and limbs developed in a 24-year-old man. They left cribriform scars after healing. Histologically, the lesions showed epidermal proliferation and pustulosis resembling that found in “pyoderma vegetans” and pemphigus vegetans. The lesions were effectively suppressed in two months by the topical application of methoxsalen followed by UV-A irradiation. Studies revealed that the chemotactic activity of polymorphonuclear leukocytes (PMNs) in the patient's peripheral blood was enhanced and that an extract of lesional crusty scales showed the presence of a PMN chemotactic factor. This factor had a molecular weight near 12,500 daltons similar to that reported in psoriasis scales. We speculate that tissue destruction due to complement activation, possibly induced by immune complex-mediated reactions in the dermis, provoked a process of transepithelial elimination of the inflammatory products.

AB - • Sterile pustules and crusted vegetative plaques on the trunk and limbs developed in a 24-year-old man. They left cribriform scars after healing. Histologically, the lesions showed epidermal proliferation and pustulosis resembling that found in “pyoderma vegetans” and pemphigus vegetans. The lesions were effectively suppressed in two months by the topical application of methoxsalen followed by UV-A irradiation. Studies revealed that the chemotactic activity of polymorphonuclear leukocytes (PMNs) in the patient's peripheral blood was enhanced and that an extract of lesional crusty scales showed the presence of a PMN chemotactic factor. This factor had a molecular weight near 12,500 daltons similar to that reported in psoriasis scales. We speculate that tissue destruction due to complement activation, possibly induced by immune complex-mediated reactions in the dermis, provoked a process of transepithelial elimination of the inflammatory products.

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Pustulosis Vegetans

Abstract

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