TY - JOUR
T1 - Pulpal response to mineral trioxide aggregate containing phosphorylated pullulan-based capping material
AU - Toida, Yu
AU - Kawano, Shimpei
AU - Islam, Rafiqul
AU - Jiale, Fu
AU - Chowdhury, A. F.M.A.
AU - Hoshika, Shuhei
AU - Shimada, Yasushi
AU - Tagami, Junji
AU - Yoshiyama, Masahiro
AU - Inoue, Satoshi
AU - Carvalho, Ricardo M.
AU - Yoshida, Yasuhiro
AU - Sano, Hidehiko
N1 - Funding Information:
The authors acknowledge Professor. T. IIMURA for his scholastic support in establishing the animal research. This research project received funding from Japan Agency for Medical Research and Development (# 26-072), a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan (# 17K11696 and 17K1169607) and UBC Start-Up funds to RMC. The authors declare no potential conflicts of interest with respect to the authorship and/or publication of this article. The authors declare no potential conflicts of interest with respect to the authorship and/or publication of this article.
Publisher Copyright:
© 2022, Japanese Society for Dental Materials and Devices. All rights reserved.
PY - 2022
Y1 - 2022
N2 - This study aimed to evaluate the pulpal responses of monkey’s pulp after direct pulp capping (DPC) with the novel mineral trioxide aggregate containing phosphorylated pullulan-based material (MTAPPL). Seventy-two teeth were randomly divided into four groups: MTAPPL; Nex-Cem MTA (NX); TheraCal LC (TH); and Dycal (DY). Histopathological changes in the pulps were observed at days 3, 7 and 70. On day 3, mild inflammatory responses were observed in the MTAPPL, no to moderate inflammatory responses in the TH, whereas moderate inflammatory responses in the NX and DY. No mineralized tissue formation (MTF) was observed in all groups. On day 7, no or mild inflammatory responses were observed in all groups. Initial MTF was observed except for DY. No inflammation with complete MTF including presence of odontoblast-like cells was observed in the MTAPPL, NX and TH groups at day 70. These findings indicate that MTAPPL could be an efficient DPC material.
AB - This study aimed to evaluate the pulpal responses of monkey’s pulp after direct pulp capping (DPC) with the novel mineral trioxide aggregate containing phosphorylated pullulan-based material (MTAPPL). Seventy-two teeth were randomly divided into four groups: MTAPPL; Nex-Cem MTA (NX); TheraCal LC (TH); and Dycal (DY). Histopathological changes in the pulps were observed at days 3, 7 and 70. On day 3, mild inflammatory responses were observed in the MTAPPL, no to moderate inflammatory responses in the TH, whereas moderate inflammatory responses in the NX and DY. No mineralized tissue formation (MTF) was observed in all groups. On day 7, no or mild inflammatory responses were observed in all groups. Initial MTF was observed except for DY. No inflammation with complete MTF including presence of odontoblast-like cells was observed in the MTAPPL, NX and TH groups at day 70. These findings indicate that MTAPPL could be an efficient DPC material.
KW - Calcium hydroxide
KW - Direct pulp capping
KW - Mineral trioxide aggregate
KW - Phosphorylated pullulan
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U2 - 10.4012/dmj.2021-153
DO - 10.4012/dmj.2021-153
M3 - Article
C2 - 34602588
AN - SCOPUS:85119275713
VL - 41
SP - 126
EP - 133
JO - Dental Materials Journal
JF - Dental Materials Journal
SN - 0287-4547
IS - 1
M1 - dmj/2021-153
ER -