Pulmonary oligometastases treated by stereotactic body radiation therapy: A nationwide survey of 1,378 patients

Yuzuru Niibe, Takaya Yamamoto, Hiroshi Onishi, Hideomi Yamashita, Kuniaki Katsui, Yasuo Matsumoto, Ryoong Jin Oh, Masahiko Aoki, Takashi Shintani, Kazunari Yamada, Mitsuru Kobayashi, Masatoki Ozaki, Yoshihiko Manabe, Katsuya Yahara, Atsushi Nishikawa, Hisao Kakuhara, Kentaro Yamamoto, Tetsuya Inoue, Yu Takada, Kenji NagataOsamu Suzuki, Atsuro Terahara, Keiichi Jingu

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Aim: This study was performed to confirm the superior overall survival (OS) after pulmonary oligo-recurrence compared to pulmonary sync-oligometastases in a large nationwide study. Patients and Methods: Patients that met the following criteria were included: 1 to 5 lung-only metastases at the beginning of stereotactic body radiation therapy (SBRT) was performed between January 2004 and June 2015, and the biological effective dose (BED) of SBRT was 75 Gy or more. The parameters included in the analyses were age, gender, ECOG PS, primary lesion, pathology, oligoetastatic state, SBRT date, chemotherapy before SBRT, chemotherapy concurrent SBRT, chemotherapy after SBRT, maximum tumor diameter, number of metastases, field coplanarity, dose prescription, BED10, OTT of SBRT. Results: In total, 1,378 patients with 1,547 tumors were enrolled. Oligo-recurrence occurred in 1,016 patients, sync-oligometastases in 118, and unclassified oligometastases in 121. The three-year OS was 64.0% for oligo-recurrence and 47.5% for sync-oligometastasis (p<0.001). In the multivariate analysis, the hazard ratio (HR) for sync-oligometastases versus oligo-recurrence was 1.601 (p=0.014). Adverse events of Grade 5 were occurred in 3 patients. Conclusion: This is the first nationwide to indicate that the OS of patients with pulmonary oligo-recurrence is better than that of patients with sync-oligometastases.

Original languageEnglish
Pages (from-to)393-399
Number of pages7
JournalAnticancer research
Issue number1
Publication statusPublished - 2020


  • Nationwide study
  • Pulmonary oligo-recurrence
  • Pulmonary oligometastases
  • Pulmonary sync-oligometastases
  • SBRT

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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