Pulmonary involvement of acute myeloid leukemia mimicking transfusion-related acute lung injury

Kentaro Ido; Yasutaka Aoyama; Joji Nagasaki; Shiro Koh; Hiroyoshi Ichihara; Hiroshi Harada; Kiyoshi Kawano; Yoshihiko Tani; Nobuki Matsuyama; Fumiya Hirayama; Masatoshi Kohsaki; Shuji Takaku; Atsuko Mugitani

doi:10.2169/internalmedicine.8505-16

Pulmonary involvement of acute myeloid leukemia mimicking transfusion-related acute lung injury

Kentaro Ido, Yasutaka Aoyama, Joji Nagasaki, Shiro Koh, Hiroyoshi Ichihara, Hiroshi Harada, Kiyoshi Kawano, Yoshihiko Tani, Nobuki Matsuyama, Fumiya Hirayama, Masatoshi Kohsaki, Shuji Takaku, Atsuko Mugitani

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Transfusion-related acute lung injury (TRALI) is defined as a new episode of acute lung injury (ALI) occurring during transfusion or within 6 hours of transfusion completion. A 66-year-old man suffering from acute myeloid leukemia developed acute respiratory distress syndrome after platelet transfusion. TRALI was diagnosed clinically, but an autopsy showed leukemic cells in diffuse pulmonary edema. Anti-human neutrophil antigen (HNA)-3a antibodies were detected in the donor serum, and the HNA-3 genotype of the patient was identified as a/a. This case was considered to represent pulmonary involvement of acute myeloid leukemia, rather than TRALI. A revision of the definition of TRALI accounting for hematological malignancies should therefore be considered.

Original language	English
Pages (from-to)	2493-2496
Number of pages	4
Journal	Internal Medicine
Volume	56
Issue number	18
DOIs	https://doi.org/10.2169/internalmedicine.8505-16
Publication status	Published - 2017
Externally published	Yes

Keywords

Acute myeloid leukemia
Autopsy
Transfusion-related acute lung injury

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.8505-16

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title = "Pulmonary involvement of acute myeloid leukemia mimicking transfusion-related acute lung injury",

abstract = "Transfusion-related acute lung injury (TRALI) is defined as a new episode of acute lung injury (ALI) occurring during transfusion or within 6 hours of transfusion completion. A 66-year-old man suffering from acute myeloid leukemia developed acute respiratory distress syndrome after platelet transfusion. TRALI was diagnosed clinically, but an autopsy showed leukemic cells in diffuse pulmonary edema. Anti-human neutrophil antigen (HNA)-3a antibodies were detected in the donor serum, and the HNA-3 genotype of the patient was identified as a/a. This case was considered to represent pulmonary involvement of acute myeloid leukemia, rather than TRALI. A revision of the definition of TRALI accounting for hematological malignancies should therefore be considered.",

keywords = "Acute myeloid leukemia, Autopsy, Transfusion-related acute lung injury",

author = "Kentaro Ido and Yasutaka Aoyama and Joji Nagasaki and Shiro Koh and Hiroyoshi Ichihara and Hiroshi Harada and Kiyoshi Kawano and Yoshihiko Tani and Nobuki Matsuyama and Fumiya Hirayama and Masatoshi Kohsaki and Shuji Takaku and Atsuko Mugitani",

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doi = "10.2169/internalmedicine.8505-16",

language = "English",

volume = "56",

pages = "2493--2496",

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TY - JOUR

T1 - Pulmonary involvement of acute myeloid leukemia mimicking transfusion-related acute lung injury

AU - Ido, Kentaro

AU - Aoyama, Yasutaka

AU - Nagasaki, Joji

AU - Koh, Shiro

AU - Ichihara, Hiroyoshi

AU - Harada, Hiroshi

AU - Kawano, Kiyoshi

AU - Tani, Yoshihiko

AU - Matsuyama, Nobuki

AU - Hirayama, Fumiya

AU - Kohsaki, Masatoshi

AU - Takaku, Shuji

AU - Mugitani, Atsuko

PY - 2017

Y1 - 2017

N2 - Transfusion-related acute lung injury (TRALI) is defined as a new episode of acute lung injury (ALI) occurring during transfusion or within 6 hours of transfusion completion. A 66-year-old man suffering from acute myeloid leukemia developed acute respiratory distress syndrome after platelet transfusion. TRALI was diagnosed clinically, but an autopsy showed leukemic cells in diffuse pulmonary edema. Anti-human neutrophil antigen (HNA)-3a antibodies were detected in the donor serum, and the HNA-3 genotype of the patient was identified as a/a. This case was considered to represent pulmonary involvement of acute myeloid leukemia, rather than TRALI. A revision of the definition of TRALI accounting for hematological malignancies should therefore be considered.

AB - Transfusion-related acute lung injury (TRALI) is defined as a new episode of acute lung injury (ALI) occurring during transfusion or within 6 hours of transfusion completion. A 66-year-old man suffering from acute myeloid leukemia developed acute respiratory distress syndrome after platelet transfusion. TRALI was diagnosed clinically, but an autopsy showed leukemic cells in diffuse pulmonary edema. Anti-human neutrophil antigen (HNA)-3a antibodies were detected in the donor serum, and the HNA-3 genotype of the patient was identified as a/a. This case was considered to represent pulmonary involvement of acute myeloid leukemia, rather than TRALI. A revision of the definition of TRALI accounting for hematological malignancies should therefore be considered.

KW - Acute myeloid leukemia

KW - Autopsy

KW - Transfusion-related acute lung injury

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DO - 10.2169/internalmedicine.8505-16

M3 - Article

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AN - SCOPUS:85029666428

SN - 0918-2918

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EP - 2496

JO - Internal Medicine

JF - Internal Medicine

IS - 18

ER -

Pulmonary involvement of acute myeloid leukemia mimicking transfusion-related acute lung injury

Abstract

Keywords

ASJC Scopus subject areas

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