Pulmonary infiltration with eosinophilia syndrome complicated with non-Hodgkin's lymphoma of B cell lineage

Makoto Fujii, Yasushi Tanimoto, Toru Kiguchi, Hideki Takehara, Yoshiaki Fujimori, Takanori Teshima, Arihiko Kanehiro, Katsuji Shinagawa, Shinya Tada, Mikio Kataoka, Mitsune Tanimoto

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Tissue eosinophilia is often seen in Hodgkin's disease and non-Hodgkin's lymphoma of T cell lineage. It is, however, rare in non-Hodgkin's lymphoma of B cell origin. We report a case of pulmonary infiltration with eosinophilia (PIE) syndrome accompanied with non-Hodgkin's lymphoma of B cell lineage. A 42-year-old man with a long-term history of bronchial asthma consulted the local hospital due to high fever and bilateral cervical lymphadenopathy. He was diagnosed as having non-Hodgkin's lymphoma and was referred to our hospital. Marked blood eosinophilia and infiltrative shadows in both middle lung fields were recognized. After six courses of chemotherapy, including prednisolone, the shadows were ameliorated, although cervical lymphadenopathy did not show any regression, indicating refractory lymphoma. To investigate pulmonary shadows, we performed transbronchial lung biopsy and bronchoalveolar lavage (BAL) at the peak of disease activity before systemic chemotherapy. The eosinophil recruiting and activating factor interleukin (IL)-5 was undetectable in both serum and BAL fluid. Moreover, in the specimen obtained from lung biopsy, tissue eosinophilia was pathologically recognized, but IL-5 was not detected by immunohistochemical staining. These findings indicate that, in this case, any factors other than IL-5 derived from lymphoma cells may be concerned with PIE.

Original languageEnglish
Pages (from-to)161-164
Number of pages4
JournalAllergology International
Volume52
Issue number3
DOIs
Publication statusPublished - Sep 2003

Fingerprint

Eosinophilia
Cell Lineage
Non-Hodgkin's Lymphoma
B-Lymphocytes
Interleukin-5
Lung
Bronchoalveolar Lavage
Lymphoma
Biopsy
Drug Therapy
Bronchoalveolar Lavage Fluid
Prednisolone
Hodgkin Disease
Fever
Asthma
Staining and Labeling
T-Lymphocytes
Serum
Lymphadenopathy

Keywords

  • Bronchoalveolar lavage fluid
  • Interleukin-5
  • Non-Hodgkin's lymphoma
  • Pulmonary infiltration with eosinophilia
  • Transbronchial lung biopsy

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Fujii, M., Tanimoto, Y., Kiguchi, T., Takehara, H., Fujimori, Y., Teshima, T., ... Tanimoto, M. (2003). Pulmonary infiltration with eosinophilia syndrome complicated with non-Hodgkin's lymphoma of B cell lineage. Allergology International, 52(3), 161-164. https://doi.org/10.1046/j.1440-1592.2003.00296.x

Pulmonary infiltration with eosinophilia syndrome complicated with non-Hodgkin's lymphoma of B cell lineage. / Fujii, Makoto; Tanimoto, Yasushi; Kiguchi, Toru; Takehara, Hideki; Fujimori, Yoshiaki; Teshima, Takanori; Kanehiro, Arihiko; Shinagawa, Katsuji; Tada, Shinya; Kataoka, Mikio; Tanimoto, Mitsune.

In: Allergology International, Vol. 52, No. 3, 09.2003, p. 161-164.

Research output: Contribution to journalArticle

Fujii, M, Tanimoto, Y, Kiguchi, T, Takehara, H, Fujimori, Y, Teshima, T, Kanehiro, A, Shinagawa, K, Tada, S, Kataoka, M & Tanimoto, M 2003, 'Pulmonary infiltration with eosinophilia syndrome complicated with non-Hodgkin's lymphoma of B cell lineage', Allergology International, vol. 52, no. 3, pp. 161-164. https://doi.org/10.1046/j.1440-1592.2003.00296.x
Fujii, Makoto ; Tanimoto, Yasushi ; Kiguchi, Toru ; Takehara, Hideki ; Fujimori, Yoshiaki ; Teshima, Takanori ; Kanehiro, Arihiko ; Shinagawa, Katsuji ; Tada, Shinya ; Kataoka, Mikio ; Tanimoto, Mitsune. / Pulmonary infiltration with eosinophilia syndrome complicated with non-Hodgkin's lymphoma of B cell lineage. In: Allergology International. 2003 ; Vol. 52, No. 3. pp. 161-164.
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