Pulmonary Enteric Adenocarcinoma Harboring a BRAF G469V Mutation

Dai Shimizu, Hiromasa Yamamoto, Kazuhiko Shien, Kohei Taniguchi, Kentaroh Miyoshi, Kei Namba, Kumi Mesaki, Seiichiro Sugimoto, Junichi Sou, Masaomi Yamane, Shinichi Toyooka

Research output: Contribution to journalArticlepeer-review

Abstract

Pulmonary enteric adenocarcinoma (PEAC) is a rare subtype of lung cancer that should be differentiated from colorectal cancer metastasis. Little is known about its genetic background. An 84-year-old male with adenocarcinoma of the lung underwent left upper lobectomy. The histology of the surgical specimen was suggestive of PEAC. Gastrointestinal and colorectal fiberscopy revealed no evidence of colorectal cancer. Next-generation sequencing of the tumor identified a G469V substitution in serine/threonine-protein kinase B-raf (BRAF). Based on the higher prevalence of the G469 substitution in BRAF-mutant lung adenocarcinoma than in BRAFmutant colorectal cancer, the tumor likely originated from the lung. Identification of mutational genotype may be of some help in distinguishing PEAC from the lung metastasis of colorectal cancer.

Original languageEnglish
Pages (from-to)759-762
Number of pages4
JournalActa medica Okayama
Volume75
Issue number6
DOIs
Publication statusPublished - Dec 1 2021

Keywords

  • next-generation sequencing
  • non-small cell lung cancer
  • non-V600E BRAF mutation
  • pulmonary adenocarcinoma with enteric differentiation
  • somatic mutations

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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