Psychophysiological stress induces heat shock cognate protein (HSC)70 mRNA in the cerebral cortex and stomach of rats

Shin Fukudo, Koji Abe, Michio Hongo, Atsushi Utsumi, Yasuto Itoyama

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Families of 70 kDa heat shock proteins have essential roles in cellular coping to noxious stimuli. However, their roles in psychophysiological stress have not been precisely clarified. We tested our hypothesis that heat shock cognate protein (HSC)70 messenger RNA would increase in stress-vulnerable organs under psychophysiological stress. In control rats, cerebral HSC70 mRNAs were constitutively expressed while gastric HSC70 mRNAs were scarcely identified. Restraint-water immersion stress significantly increased the level of cerebral HSC70 mRNAs for 6 h and 12 h. Stress for 6 h with recovery for 6 h induced more gastric HSC70 mRNA levels than that without recovery, while stress for 12 h expressed the highest gastric HCS70 mRNA levels. Hypothermia, induced by water immersion, excluded a possible role of hyperthermia in inducing HSC70 mRNA. Our results point to a crucial cytoprotective role for families of heat shock proteins in stress-vulnerable brain-gut link in mammals under psychophysiological stress.

Original languageEnglish
Pages (from-to)98-102
Number of pages5
JournalBrain Research
Volume675
Issue number1-2
DOIs
Publication statusPublished - Mar 27 1995
Externally publishedYes

Fingerprint

HSC70 Heat-Shock Proteins
Cerebral Cortex
Stomach
Messenger RNA
Immersion
Induced Hypothermia
HSP70 Heat-Shock Proteins
Heat-Shock Proteins
Dehydration
Mammals
Fever
Water
Brain

Keywords

  • Cerebral cortex
  • Heat shock cognate protein 70
  • Heat shock protein
  • Messenger RNA
  • Northern blotting
  • Rat
  • Restraint-water immersion stress
  • Stomach

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Psychophysiological stress induces heat shock cognate protein (HSC)70 mRNA in the cerebral cortex and stomach of rats. / Fukudo, Shin; Abe, Koji; Hongo, Michio; Utsumi, Atsushi; Itoyama, Yasuto.

In: Brain Research, Vol. 675, No. 1-2, 27.03.1995, p. 98-102.

Research output: Contribution to journalArticle

Fukudo, Shin ; Abe, Koji ; Hongo, Michio ; Utsumi, Atsushi ; Itoyama, Yasuto. / Psychophysiological stress induces heat shock cognate protein (HSC)70 mRNA in the cerebral cortex and stomach of rats. In: Brain Research. 1995 ; Vol. 675, No. 1-2. pp. 98-102.
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