Pseudomalabsorption of Levothyroxine: A Case Report

Daisuke Ogawa, Fumio Otsuka, Yukari Mimura, Akiko Ueno, Hiroo Hashimoto, Masayuki Kishida, Toshio Ogura, Hirofumi Makino

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

A 51-year-old woman who had been treated with levothyroxine sodium because of hypothyroidism after total thyroidectomy for thyroidal cancer was admitted to our hospital for persistent hypothyroidism despite large dose administration of levothyroxine (600 μg/day). The patient complained of severe general fatigue and body weight gain. Free thyroxine, free triiodothyronine and thyrotropin levels were 0.97 ng/dl, 1.55 pg/ml and 24.51 μU/ml, respectively, under oral administration of levothyroxine. Levothyroxine loading test performed by liquid form, pulverized tablets via nasogastric tube and intravenous administration revealed no evidence of malabsorption or metabolic disorder of levothyroxine, although oral intake of tablets was ineffective due to her factitiousness. We report here a possible case of "pseudomalabsorption of levothyroxine" to emphasize the clinical recognition of this disorder in patients with resistant hypothyroidism.

Original languageEnglish
Pages (from-to)45-50
Number of pages6
JournalEndocrine journal
Volume47
Issue number1
DOIs
Publication statusPublished - Feb 2000

Keywords

  • Hypothyroidism
  • Munchausen syndrome
  • Thyroid carcinoma

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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