Pruritus-associated response mediated by cutaneous histamine H3 receptors

Yukio Sugimoto, Y. Iba, Y. Nakamura, R. Kayasuga, C. Kamei

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Background: Histamine is one of the most common chemical mediators causing pruritus, and H1 receptor antagonists have been used as a first choice in its treatment. On the other hand, although the presence of H 3 receptors has been identified in the skin, few studies have investigated the involvement of H3 receptors on pruritus. Objective: The purpose of this study was to examine whether H3 receptor agonist or antagonist influences the incidence of scratching behaviour in ICR or mast cell-deficient WBB6F1-W/Wv mice. Methods: The mice were given an intradermal injection of H3 receptor agonist or antagonist into the rostral part of the back, and the occurrence of scratching behaviour at the injected site by the hind paws was counted over 60 min. Results: H 3 receptor antagonists, thioperamide and AQO145 significantly increased the incidence of scratching behaviour in ICR mice. H3 receptor agonist, (R)-alpha-methylhistamine, had no effect. On the other hand, (R)-alpha-methylhistamine significantly inhibited thioperamide or AQO145-induced scratching behaviour. In addition, both thioperamide and AQ0145 elicited scratching behaviour in mast cell-deficient WBB6F1-W/W v mice. Conclusion: From these results, it may be concluded that H3 receptors are involved in the modulation of pruritus in the skin, and mast cells are not essential in this response. In addition, H3 receptor agonists can be useful as a novel therapeutic approach against pruritus.

Original languageEnglish
Pages (from-to)456-459
Number of pages4
JournalClinical and Experimental Allergy
Volume34
Issue number3
DOIs
Publication statusPublished - Mar 2004

Fingerprint

Histamine H3 Receptors
thioperamide
Pruritus
Histamine Agonists
alpha-methylhistamine
Skin
Mast Cells
Intradermal Injections
Histamine H1 Receptors
Inbred ICR Mouse
Incidence
Histamine
Therapeutics

Keywords

  • (R)-alpha-methylhistamine
  • AQ0145
  • H agonist
  • H antagonist
  • H receptor
  • Scratching behaviour
  • Thioperamide
  • WBB6F -W/W mice

ASJC Scopus subject areas

  • Immunology

Cite this

Pruritus-associated response mediated by cutaneous histamine H3 receptors. / Sugimoto, Yukio; Iba, Y.; Nakamura, Y.; Kayasuga, R.; Kamei, C.

In: Clinical and Experimental Allergy, Vol. 34, No. 3, 03.2004, p. 456-459.

Research output: Contribution to journalArticle

Sugimoto, Yukio ; Iba, Y. ; Nakamura, Y. ; Kayasuga, R. ; Kamei, C. / Pruritus-associated response mediated by cutaneous histamine H3 receptors. In: Clinical and Experimental Allergy. 2004 ; Vol. 34, No. 3. pp. 456-459.
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