Proteome analysis of new antimalarial endoperoxide against Plasmodium falciparum

Nagwa S.M. Aly, Akiko Hiramoto, Hitomi Sanai, Osamu Hiraoka, Kazuyuki Hiramoto, Hiroyuki Kataoka, Jin Ming Wu, Araki Masuyama, Masatomo Nojima, Satoru Kawai, Hye Sook Kim, Yusuke Wataya

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

N-89, a new antimalarial endoperoxide, was selected as a promising antimalarial compound showing high activity and selectivity. To study the mechanism of N-89 action, N-89 resistant strain (NRC10) was obtained by intermittent drug pressure. NRC10 had a tenfold increase in the EC50 value of N-89. No cross-resistance was obtained with other antimalarial compounds. Comparative proteome analysis of N-89 sensitive and NRC10 strains revealed over-expression of 12 spots and down-regulation of 14 spots in NRC10. Fifteen proteins were identified of Plasmodium falciparum origin. The identified proteins representing several functions, mainly related to the glycolytic pathway, and metabolism of protein and lipid. Our results suggest that identified proteins may be candidates of antimalarial endoperoxide targets.

Original languageEnglish
Pages (from-to)1119-1124
Number of pages6
JournalParasitology Research
Volume100
Issue number5
DOIs
Publication statusPublished - Apr 1 2007

ASJC Scopus subject areas

  • Parasitology
  • veterinary(all)
  • Insect Science
  • Infectious Diseases

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