Abstract
With the elucidation of the human genome, exhaustive analysis of genomic data related to gene transcription and the structure and function of translated protein products has progressed rapidly. Delivery of proteins and their functional domains or inhibitory peptides directly into the cell is ideal to use this protein information and analyze associated physiological functions. Protein transduction technology, which controls cell function via direct delivery of a desired protein into the cell, involves fusing the protein with a special peptide sequence consisting of 10-20 amino acids, referred to as the protein transduction domain. The recent discovery that the protein transduction domain can also be inserted into various macromolecules heightens expectations in terms of development of novel advanced experimental tools and clinical reagents.
| Original language | English |
|---|---|
| Pages (from-to) | 324-328 |
| Number of pages | 5 |
| Journal | Journal of Molecular Medicine |
| Volume | 83 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 2005 |
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Keywords
- Gene therapy
- Gene transcription
- Gene-translated protein
- Protein transduction domain
- Protein transduction technology
ASJC Scopus subject areas
- Medicine(all)
Cite this
Protein transduction technology. / Matsushita, Masayuki; Matsui, Hideki.
In: Journal of Molecular Medicine, Vol. 83, No. 5, 05.2005, p. 324-328.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Protein transduction technology
AU - Matsushita, Masayuki
AU - Matsui, Hideki
PY - 2005/5
Y1 - 2005/5
N2 - With the elucidation of the human genome, exhaustive analysis of genomic data related to gene transcription and the structure and function of translated protein products has progressed rapidly. Delivery of proteins and their functional domains or inhibitory peptides directly into the cell is ideal to use this protein information and analyze associated physiological functions. Protein transduction technology, which controls cell function via direct delivery of a desired protein into the cell, involves fusing the protein with a special peptide sequence consisting of 10-20 amino acids, referred to as the protein transduction domain. The recent discovery that the protein transduction domain can also be inserted into various macromolecules heightens expectations in terms of development of novel advanced experimental tools and clinical reagents.
AB - With the elucidation of the human genome, exhaustive analysis of genomic data related to gene transcription and the structure and function of translated protein products has progressed rapidly. Delivery of proteins and their functional domains or inhibitory peptides directly into the cell is ideal to use this protein information and analyze associated physiological functions. Protein transduction technology, which controls cell function via direct delivery of a desired protein into the cell, involves fusing the protein with a special peptide sequence consisting of 10-20 amino acids, referred to as the protein transduction domain. The recent discovery that the protein transduction domain can also be inserted into various macromolecules heightens expectations in terms of development of novel advanced experimental tools and clinical reagents.
KW - Gene therapy
KW - Gene transcription
KW - Gene-translated protein
KW - Protein transduction domain
KW - Protein transduction technology
UR - http://www.scopus.com/inward/record.url?scp=22544470766&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=22544470766&partnerID=8YFLogxK
U2 - 10.1007/s00109-004-0633-1
DO - 10.1007/s00109-004-0633-1
M3 - Article
C2 - 15703950
AN - SCOPUS:22544470766
VL - 83
SP - 324
EP - 328
JO - Journal of Molecular Medicine
JF - Journal of Molecular Medicine
SN - 0946-2716
IS - 5
ER -