Protein transduction by poly-arginine

Hideki Matsui, Kazuhito Tomizawa, Masayuki Matsushita

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Protein transduction methods have been developed utilizing the delivery of peptides and proteins into eukaryotic cells by the protein transduction domain (PTD). Initially, the PTD domain was developed from the sequences from HIV-1 TAT, HSV VP-22 and antennapedia homeoprotein. Recently, several novel PTDs were developed and has been used as a valuable strategy for transduction of therapeutic protein. We developed a novel, high efficiency PTD (11 arginine) based on the TAT sequence and used 11R for the regulation of intracellular signal cascades. PTD can deliver proteins and other bioactive compounds and therefore serves as a very useful strategy for the development of therapeutic agents.

Original languageEnglish
Pages (from-to)435-439
Number of pages5
JournalFolia Pharmacologica Japonica
Volume121
Issue number6
DOIs
Publication statusPublished - 2003

Keywords

  • PTD
  • Polyarginine
  • Protein therapy
  • Protein transduction
  • TAT

ASJC Scopus subject areas

  • Pharmacology

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