Protein phosphatase 1 modulation of neostriatal AMPA channels

Regulation by DARPP-32 and spinophilin

Zhen Yan, Linda Hsieh-Wilson, Jian Feng, Kazuhito Tomizawa, Patrick B. Allen, Allen A. Fienberg, Angus C. Nairn, Paul Greengard

Research output: Contribution to journalArticle

234 Citations (Scopus)

Abstract

Modulation of AMPA-type glutamate channels is important for synaptic plasticity. Here we provide physiological evidence that the activity of AMPA channels is regulated by protein phosphatase 1 (PP-1) in neostriatal neurons and identify two distinct molecular mechanisms of this regulation. One mechanism involves control of PP-1 catalytic activity by DARPP-32, a dopamine- and cAMP-regulated phosphoprotein highly enriched in neostriatum. The other involves binding of PP-1 to spinophilin, a protein that colocalizes PP-1 with AMPA receptors in postsynaptic densities. The results suggest that regulation of anchored PP-1 is important for AMPA-receptor-mediated synaptic transmission and plasticity.

Original languageEnglish
Pages (from-to)13-17
Number of pages5
JournalNature Neuroscience
Volume2
Issue number1
DOIs
Publication statusPublished - Jan 1 1999
Externally publishedYes

Fingerprint

Protein Phosphatase 1
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Neuronal Plasticity
AMPA Receptors
Dopamine and cAMP-Regulated Phosphoprotein 32
Neostriatum
Post-Synaptic Density
Synaptic Transmission
Glutamic Acid
Carrier Proteins
neurabin
Neurons
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Yan, Z., Hsieh-Wilson, L., Feng, J., Tomizawa, K., Allen, P. B., Fienberg, A. A., ... Greengard, P. (1999). Protein phosphatase 1 modulation of neostriatal AMPA channels: Regulation by DARPP-32 and spinophilin. Nature Neuroscience, 2(1), 13-17. https://doi.org/10.1038/4516

Protein phosphatase 1 modulation of neostriatal AMPA channels : Regulation by DARPP-32 and spinophilin. / Yan, Zhen; Hsieh-Wilson, Linda; Feng, Jian; Tomizawa, Kazuhito; Allen, Patrick B.; Fienberg, Allen A.; Nairn, Angus C.; Greengard, Paul.

In: Nature Neuroscience, Vol. 2, No. 1, 01.01.1999, p. 13-17.

Research output: Contribution to journalArticle

Yan, Z, Hsieh-Wilson, L, Feng, J, Tomizawa, K, Allen, PB, Fienberg, AA, Nairn, AC & Greengard, P 1999, 'Protein phosphatase 1 modulation of neostriatal AMPA channels: Regulation by DARPP-32 and spinophilin', Nature Neuroscience, vol. 2, no. 1, pp. 13-17. https://doi.org/10.1038/4516
Yan, Zhen ; Hsieh-Wilson, Linda ; Feng, Jian ; Tomizawa, Kazuhito ; Allen, Patrick B. ; Fienberg, Allen A. ; Nairn, Angus C. ; Greengard, Paul. / Protein phosphatase 1 modulation of neostriatal AMPA channels : Regulation by DARPP-32 and spinophilin. In: Nature Neuroscience. 1999 ; Vol. 2, No. 1. pp. 13-17.
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