Protein degradation machineries in plastids

    Research output: Contribution to journalReview articlepeer-review

    173 Citations (Scopus)


    Plastids undergo drastic morphological and physiological changes under different developmental stages and in response to environmental conditions. A key to accomplishing these transitions and maintaining homeostasis is the quality and quantity control of many plastid proteins by proteases and chaperones. Although a limited number of plastid proteases have been identified by biochemical approaches; recent progress in genome information revealed various plant proteases that are of prokaryotic origin and that are localized in chloroplasts. Of these, ATP-dependent proteases such as Clp, FtsH, and Lon are considered the major enzymes involved in processive degradation (gradual degradation to oligopeptides and amino acids). The basic architecture of plant ATP-dependent proteases is very similar to the architechture of bacterial enzymes, such as those in Escherichia coli, but plastid enzymes apparently have extraordinary numbers of isomers. Recent molecular genetic characterization in Arabidopsis has identified differential roles of these isomers. This review covers what is currently known about the types and function of plastid proteases together with our new observations.

    Original languageEnglish
    Pages (from-to)599-621
    Number of pages23
    JournalAnnual Review of Plant Biology
    Publication statusPublished - 2006


    • ATP-dependent proteolysis
    • Photosynthesis and oxidative damage
    • Plastid and chloroplast
    • Protease
    • Thylakoid membranes

    ASJC Scopus subject areas

    • Physiology
    • Molecular Biology
    • Plant Science
    • Cell Biology


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