Protective role of heme oxygenase-1 in Listeria monocytogenes-induced abortion

Masato Tachibana, Masanori Hashino, Takashi Nishida, Takashi Shimizu, Masahisa Watarai

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

It is well-known fact that various pathogens, including bacteria, virus, and protozoa, induce abortion in humans and animals. However the mechanisms of infectious abortion are little known. In this study, we demonstrated that Listeria monocytogenes infection in trophoblast giant cells decreased heme oxygenase (HO)-1 and B-cell lymphoma-extra large (Bcl-XL) expression, and that their overexpression inhibited cell death induced by the infection. Furthermore, HO-1 and Bcl-XL expression levels were also decreased by L. monocytogenes in pregnant mice. Treatment with cobalt protoporphyrin, which is known to induce HO-1, inhibited infectious abortion. Taken together, our study indicates that L. monocytogenes infection decreases HO-1 and Bcl-XL expression and induces cell death in placenta, leading to infectious abortion.

Original languageEnglish
Article numbere25046
JournalPloS one
Volume6
Issue number9
DOIs
Publication statusPublished - Sep 16 2011
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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