Protective responses against experimental Mycobacterium leprae infection in mice induced by recombinant Bacillus Calmette-Guérin over-producing three putative protective antigen candidates

Naoya Ohara, Masanori Matsuoka, Hiroko Nomaguchi, Mariko Naito, Takeshi Yamada

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

The components of Ag85 (Ag85A, Ag85B, and Ag85C) are putative protective antigen candidates against mycobacterial infection. A recombinant Mycobacterium bovis Bacillus Calmette-Guérin (rBCG) over-producing Ag85A, Ag85B, and MPB51 (rBCG/BA51) was constructed. rBCG/BA51 could secrete these antigens at levels more than five times higher than parental BCG. Immunization of C57BL/6 and BALB/c mice with this rBCG reduced the multiplication of Mycobacterium leprae in the foot pads of both strains of mice. The inhibition by rBCG/BA51 was more evident than that by parental BCG.

Original languageEnglish
Pages (from-to)1906-1910
Number of pages5
JournalVaccine
Volume19
Issue number15-16
DOIs
Publication statusPublished - Feb 28 2001
Externally publishedYes

Keywords

  • Ag85
  • BCG
  • Leprosy
  • Recombinant
  • Vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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