Protective effects of radon inhalation on carrageenan-induced inflammatory paw edema in mice

Takahiro Kataoka, Junichi Teraoka, Akihiro Sakoda, Yuichi Nishiyama, Keiko Yamato, Mayuko Monden, Yuu Ishimori, Takaharu Nomura, Takehito Taguchi, Kiyonori Yamaoka

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

We assessed whether radon inhalation inhibited carrageenan-induced inflammation in mice. Carrageenan (1% v/v) was injected subcutaneously into paws of mice that had or had not inhaled approximately 2,000 Bq/m3 of radon for 24 h. Radon inhalation significantly increased superoxide dismutase (SOD) and catalase activities and significantly decreased lipid peroxide levels in mouse paws, indicating that radon inhalation activates antioxidative functions. Carrageenan administration induced paw edema and significantly increased tumor necrosis factor-alpha (TNF-α) and nitric oxide in serum. However, radon inhalation significantly reduced carrageenan-induced paw edema. Serum TNF-α levels were lower in the radon-treated mice than in sham-treated mice. In addition, SOD and catalase activities in paws were significantly higher in the radon-treated mice than in the sham-treated mice. These findings indicated that radon inhalation had anti-inflammatory effects and inhibited carrageenan-induced inflammatory paw edema.

Original languageEnglish
Pages (from-to)713-722
Number of pages10
JournalInflammation
Volume35
Issue number2
DOIs
Publication statusPublished - Apr 2012

Keywords

  • Antioxidative function
  • Carrageenan
  • Edema
  • Inflammation
  • Radon inhalation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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