Protective effects of interferon-γ against methamphetamine-induced neurotoxicity

Hiroaki Hozumi, Masato Asanuma, Ikuko Miyazaki, Saki Fukuoka, Yuri Kikkawa, Naotaka Kimoto, Yoshihisa Kitamura, Toshiaki Sendo, Taizo Kita, Yutaka Gomita

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Repeated injections of methamphetamine (METH) cause degeneration of striatal dopaminergic nerve terminals. In the present study, we examined the effects of interferon-γ (IFN-γ) on METH-induced striatal neurotoxicity in mice. Intraperitoneal injection of IFN-γ before METH injection significantly prevented METH-induced reduction of striatal dopamine transporter (DAT)-positive signals and hyperthermia. Furthermore, intracerebroventricular injection of IFN-γ before METH treatment markedly prevented METH-induced reduction of DAT. Interestingly, central IFN-γ injection had no effect on METH-induced hyperthermia. In addition, IFN-γ injected centrally after METH treatment, but not systemically, 1 h after the final METH injection significantly protected against METH-induced neurotoxicity. Our results suggest that IFN-γ injected systemically or its related molecule protects against METH-induced neurotoxicity through intracerebral molecular pathways, while it can prevent METH-induced hyperthermia through different molecular events.

Original languageEnglish
Pages (from-to)123-129
Number of pages7
JournalToxicology Letters
Volume177
Issue number2
DOIs
Publication statusPublished - Mar 15 2008

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Methamphetamine
Interferons
Corpus Striatum
Injections
Dopamine Plasma Membrane Transport Proteins
Induced Hyperthermia
Intraperitoneal Injections
Fever

Keywords

  • Dopamine transporter
  • Hyperthermia
  • Interferon-γ
  • Methamphetamine
  • Neuroprotection
  • Neurotoxicity

ASJC Scopus subject areas

  • Toxicology

Cite this

Protective effects of interferon-γ against methamphetamine-induced neurotoxicity. / Hozumi, Hiroaki; Asanuma, Masato; Miyazaki, Ikuko; Fukuoka, Saki; Kikkawa, Yuri; Kimoto, Naotaka; Kitamura, Yoshihisa; Sendo, Toshiaki; Kita, Taizo; Gomita, Yutaka.

In: Toxicology Letters, Vol. 177, No. 2, 15.03.2008, p. 123-129.

Research output: Contribution to journalArticle

Hozumi, Hiroaki ; Asanuma, Masato ; Miyazaki, Ikuko ; Fukuoka, Saki ; Kikkawa, Yuri ; Kimoto, Naotaka ; Kitamura, Yoshihisa ; Sendo, Toshiaki ; Kita, Taizo ; Gomita, Yutaka. / Protective effects of interferon-γ against methamphetamine-induced neurotoxicity. In: Toxicology Letters. 2008 ; Vol. 177, No. 2. pp. 123-129.
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