Abstract
Repeated injections of methamphetamine (METH) cause degeneration of striatal dopaminergic nerve terminals. In the present study, we examined the effects of interferon-γ (IFN-γ) on METH-induced striatal neurotoxicity in mice. Intraperitoneal injection of IFN-γ before METH injection significantly prevented METH-induced reduction of striatal dopamine transporter (DAT)-positive signals and hyperthermia. Furthermore, intracerebroventricular injection of IFN-γ before METH treatment markedly prevented METH-induced reduction of DAT. Interestingly, central IFN-γ injection had no effect on METH-induced hyperthermia. In addition, IFN-γ injected centrally after METH treatment, but not systemically, 1 h after the final METH injection significantly protected against METH-induced neurotoxicity. Our results suggest that IFN-γ injected systemically or its related molecule protects against METH-induced neurotoxicity through intracerebral molecular pathways, while it can prevent METH-induced hyperthermia through different molecular events.
| Original language | English |
|---|---|
| Pages (from-to) | 123-129 |
| Number of pages | 7 |
| Journal | Toxicology Letters |
| Volume | 177 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Mar 15 2008 |
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Keywords
- Dopamine transporter
- Hyperthermia
- Interferon-γ
- Methamphetamine
- Neuroprotection
- Neurotoxicity
ASJC Scopus subject areas
- Toxicology
Cite this
Protective effects of interferon-γ against methamphetamine-induced neurotoxicity. / Hozumi, Hiroaki; Asanuma, Masato; Miyazaki, Ikuko; Fukuoka, Saki; Kikkawa, Yuri; Kimoto, Naotaka; Kitamura, Yoshihisa; Sendo, Toshiaki; Kita, Taizo; Gomita, Yutaka.
In: Toxicology Letters, Vol. 177, No. 2, 15.03.2008, p. 123-129.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Protective effects of interferon-γ against methamphetamine-induced neurotoxicity
AU - Hozumi, Hiroaki
AU - Asanuma, Masato
AU - Miyazaki, Ikuko
AU - Fukuoka, Saki
AU - Kikkawa, Yuri
AU - Kimoto, Naotaka
AU - Kitamura, Yoshihisa
AU - Sendo, Toshiaki
AU - Kita, Taizo
AU - Gomita, Yutaka
PY - 2008/3/15
Y1 - 2008/3/15
N2 - Repeated injections of methamphetamine (METH) cause degeneration of striatal dopaminergic nerve terminals. In the present study, we examined the effects of interferon-γ (IFN-γ) on METH-induced striatal neurotoxicity in mice. Intraperitoneal injection of IFN-γ before METH injection significantly prevented METH-induced reduction of striatal dopamine transporter (DAT)-positive signals and hyperthermia. Furthermore, intracerebroventricular injection of IFN-γ before METH treatment markedly prevented METH-induced reduction of DAT. Interestingly, central IFN-γ injection had no effect on METH-induced hyperthermia. In addition, IFN-γ injected centrally after METH treatment, but not systemically, 1 h after the final METH injection significantly protected against METH-induced neurotoxicity. Our results suggest that IFN-γ injected systemically or its related molecule protects against METH-induced neurotoxicity through intracerebral molecular pathways, while it can prevent METH-induced hyperthermia through different molecular events.
AB - Repeated injections of methamphetamine (METH) cause degeneration of striatal dopaminergic nerve terminals. In the present study, we examined the effects of interferon-γ (IFN-γ) on METH-induced striatal neurotoxicity in mice. Intraperitoneal injection of IFN-γ before METH injection significantly prevented METH-induced reduction of striatal dopamine transporter (DAT)-positive signals and hyperthermia. Furthermore, intracerebroventricular injection of IFN-γ before METH treatment markedly prevented METH-induced reduction of DAT. Interestingly, central IFN-γ injection had no effect on METH-induced hyperthermia. In addition, IFN-γ injected centrally after METH treatment, but not systemically, 1 h after the final METH injection significantly protected against METH-induced neurotoxicity. Our results suggest that IFN-γ injected systemically or its related molecule protects against METH-induced neurotoxicity through intracerebral molecular pathways, while it can prevent METH-induced hyperthermia through different molecular events.
KW - Dopamine transporter
KW - Hyperthermia
KW - Interferon-γ
KW - Methamphetamine
KW - Neuroprotection
KW - Neurotoxicity
UR - http://www.scopus.com/inward/record.url?scp=39749102168&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=39749102168&partnerID=8YFLogxK
U2 - 10.1016/j.toxlet.2008.01.005
DO - 10.1016/j.toxlet.2008.01.005
M3 - Article
VL - 177
SP - 123
EP - 129
JO - Toxicology Letters
JF - Toxicology Letters
SN - 0378-4274
IS - 2
ER -