Abstract
Repeated injections of methamphetamine (METH) cause degeneration of striatal dopaminergic nerve terminals. In the present study, we examined the effects of interferon-γ (IFN-γ) on METH-induced striatal neurotoxicity in mice. Intraperitoneal injection of IFN-γ before METH injection significantly prevented METH-induced reduction of striatal dopamine transporter (DAT)-positive signals and hyperthermia. Furthermore, intracerebroventricular injection of IFN-γ before METH treatment markedly prevented METH-induced reduction of DAT. Interestingly, central IFN-γ injection had no effect on METH-induced hyperthermia. In addition, IFN-γ injected centrally after METH treatment, but not systemically, 1 h after the final METH injection significantly protected against METH-induced neurotoxicity. Our results suggest that IFN-γ injected systemically or its related molecule protects against METH-induced neurotoxicity through intracerebral molecular pathways, while it can prevent METH-induced hyperthermia through different molecular events.
Original language | English |
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Pages (from-to) | 123-129 |
Number of pages | 7 |
Journal | Toxicology Letters |
Volume | 177 |
Issue number | 2 |
DOIs | |
Publication status | Published - Mar 15 2008 |
Keywords
- Dopamine transporter
- Hyperthermia
- Interferon-γ
- Methamphetamine
- Neuroprotection
- Neurotoxicity
ASJC Scopus subject areas
- Toxicology