Protective effects of bisoprolol against acute exacerbation in moderate-to-severe chronic obstructive pulmonary disease

Akihiko Taniguchi, Nobuaki Miyahara, Naohiro Oda, Daisuke Morichika, Eiki Ichihara, Isao Ozed, Yasushi Tanimoto, Hirohisa Ichikawa, Utako Fujii, Mitsune Tanimoto, Arihiko Kanehiro, Katsuyuki Kiura

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Although recent retrospective studies suggested that the use of β-blockers appears to help improve the mortality rate and decrease the rate of exacerbation in chronic obstructive pulmonary disease (COPD) patients with heart failure, the effects of β-blockers on COPD patients without heart failure have not been established. Based on previous reports, we have launched a multicenter, prospective, single-arm phase II study to evaluate the preventive effect of the cardioselective β-blocker bisoprolol in COPD exacerbation, in Japanese individuals with moderate-to-severe COPD who do not have heart failure but do have hypertension requiring the use of medication. The primary endpoint is the rate of mild-to-severe COPD exacerbation. The results of this study will clarify whether bisoprolol can prevent exacerbation in COPD patients without heart failure.

Original languageEnglish
Pages (from-to)453-457
Number of pages5
JournalActa medica Okayama
Volume71
Issue number5
Publication statusPublished - 2017

Keywords

  • Bisoprolol
  • Chronic obstructive pulmonary disease
  • Exacerbation
  • Heart failure
  • β-blocker

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Taniguchi, A., Miyahara, N., Oda, N., Morichika, D., Ichihara, E., Ozed, I., Tanimoto, Y., Ichikawa, H., Fujii, U., Tanimoto, M., Kanehiro, A., & Kiura, K. (2017). Protective effects of bisoprolol against acute exacerbation in moderate-to-severe chronic obstructive pulmonary disease. Acta medica Okayama, 71(5), 453-457.