Protective effect of vagus nerve stimulation on forebrain ischaemia in gerbil hippocampus

Tetsuya Masada; Toshifumi Itano; Mutsuo Fujisawa; Osamu Miyamoto; Masaaki Tokuda; Hideki Matsui; Seigo Nagao; Osamu Hatase

doi:10.1097/00001756-199601310-00017

Protective effect of vagus nerve stimulation on forebrain ischaemia in gerbil hippocampus

Tetsuya Masada, Toshifumi Itano, Mutsuo Fujisawa, Osamu Miyamoto, Masaaki Tokuda, Hideki Matsui, Seigo Nagao, Osamu Hatase

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

The left vagus nerve was stimulated during transient forebrain ischaemia in gerbils. The animals were exposed to 3 min of forebrain ischaemic insult at 37.5°C. On day 5 post-ischaemia, the animals were perfusion-fixed for qualitative and quantitative histopathological analyses. High current stimulation of the vagus nerve inhibited ischaemic neuronal damage in the hippocampal CA1 sector (p < 0.01), but low current stimulation did not (p < 0.01). These effects might have been due to inhibition of the effects of excitatory amino acids during ischaemia. These results indicate that vagus nerve stimulation might be protective to neurones subjected to ischaemic insult.

Original language	English
Pages (from-to)	446-448
Number of pages	3
Journal	NeuroReport
Volume	7
Issue number	2
DOIs	https://doi.org/10.1097/00001756-199601310-00017
Publication status	Published - Jan 1 1996

Keywords

CA1
gerbil
glutamate
hippocampus
ischaemia
vagus nerve stimulation

ASJC Scopus subject areas

Neuroscience(all)

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10.1097/00001756-199601310-00017

Cite this

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abstract = "The left vagus nerve was stimulated during transient forebrain ischaemia in gerbils. The animals were exposed to 3 min of forebrain ischaemic insult at 37.5°C. On day 5 post-ischaemia, the animals were perfusion-fixed for qualitative and quantitative histopathological analyses. High current stimulation of the vagus nerve inhibited ischaemic neuronal damage in the hippocampal CA1 sector (p < 0.01), but low current stimulation did not (p < 0.01). These effects might have been due to inhibition of the effects of excitatory amino acids during ischaemia. These results indicate that vagus nerve stimulation might be protective to neurones subjected to ischaemic insult.",

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AU - Fujisawa, Mutsuo

AU - Miyamoto, Osamu

AU - Tokuda, Masaaki

AU - Matsui, Hideki

AU - Nagao, Seigo

AU - Hatase, Osamu

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Protective effect of vagus nerve stimulation on forebrain ischaemia in gerbil hippocampus

Abstract

Keywords

ASJC Scopus subject areas

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