Protective effect of eicosapentaenoic acid on insulin resistance in hyperlipidemic patients and on the postoperative course of cardiac surgery patients: The possible involvement of adiponectin

Tsuyoshi Yamamoto, Yutaka Kajikawa, Satoru Otani, Yuki Yamada, Syunji Takemoto, Minoru Hirota, Masae Ikeda, Hiromi Iwagaki, Shinya Saito, Toshiyoshi Fujiwara

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Accumulated studies have shown that ω-3 polyunsaturated fatty acids such as eicosapentaenoic acid (EPA) have protective roles against inflammatory responses such as hyperlipidemia, diabetes mellitus (DM) and cardiovascular diseases. Here we examined the effects of administering EPA to hyperlipidemic patients and other patients undergoing cardiac surgery to determine whether this treatment would increase plasma EPA levels and to clarify the association between EPA treatment and adiponectin production in hyperlipidemic patients. We also assessed the effect of preoperative EPA administration on postoperative adverse events such as postoperative atrial fibrillation (POAF) and postoperative infection in the cardiac surgery patients. The EPA administration significantly increased the serum EPA concentrations in both patient populations (p

Original languageEnglish
Pages (from-to)349-361
Number of pages13
JournalActa Medica Okayama
Volume68
Issue number6
Publication statusPublished - 2014

Fingerprint

Eicosapentaenoic Acid
Adiponectin
Surgery
Thoracic Surgery
Insulin Resistance
Insulin
Medical problems
Hyperlipidemias
Unsaturated Fatty Acids
Atrial Fibrillation
Diabetes Mellitus
Cardiovascular Diseases
Plasmas
Therapeutics
Infection
Serum
Population

Keywords

  • Adiponectin
  • Atrial fibrillation
  • Cardiac surgery
  • Eicosapentaenoic acid
  • Hyperlipidemic patients

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Protective effect of eicosapentaenoic acid on insulin resistance in hyperlipidemic patients and on the postoperative course of cardiac surgery patients : The possible involvement of adiponectin. / Yamamoto, Tsuyoshi; Kajikawa, Yutaka; Otani, Satoru; Yamada, Yuki; Takemoto, Syunji; Hirota, Minoru; Ikeda, Masae; Iwagaki, Hiromi; Saito, Shinya; Fujiwara, Toshiyoshi.

In: Acta Medica Okayama, Vol. 68, No. 6, 2014, p. 349-361.

Research output: Contribution to journalArticle

Yamamoto, Tsuyoshi ; Kajikawa, Yutaka ; Otani, Satoru ; Yamada, Yuki ; Takemoto, Syunji ; Hirota, Minoru ; Ikeda, Masae ; Iwagaki, Hiromi ; Saito, Shinya ; Fujiwara, Toshiyoshi. / Protective effect of eicosapentaenoic acid on insulin resistance in hyperlipidemic patients and on the postoperative course of cardiac surgery patients : The possible involvement of adiponectin. In: Acta Medica Okayama. 2014 ; Vol. 68, No. 6. pp. 349-361.
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