Abstract
Heme oxygenase (HO) catabolizes heme into three products: carbon monoxide (CO), biliverdin and free iron. HO-1, inducible form of HO, has been shown to be protective against various stress. CO at a low concentration has been shown to be protective in several disease models mimicking the action of HO-1. We suggest that CO, the byproduct of heme degradation, could be valuable therapeutic agents. We review the functional role of HO-1 and CO and its potential application to clinical settings.
| Original language | English |
|---|---|
| Pages (from-to) | 309-313 |
| Number of pages | 5 |
| Journal | Nippon Geka Gakkai zasshi |
| Volume | 105 |
| Issue number | 4 |
| Publication status | Published - 2004 |
| Externally published | Yes |
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Protective effect of carbon monoxide for organ injury. / Nakao, Atsunori; Kobayashi, Eiji; Tanaka, Noriaki; Murase, Noriko.
In: Nippon Geka Gakkai zasshi, Vol. 105, No. 4, 2004, p. 309-313.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Protective effect of carbon monoxide for organ injury
AU - Nakao, Atsunori
AU - Kobayashi, Eiji
AU - Tanaka, Noriaki
AU - Murase, Noriko
PY - 2004
Y1 - 2004
N2 - Heme oxygenase (HO) catabolizes heme into three products: carbon monoxide (CO), biliverdin and free iron. HO-1, inducible form of HO, has been shown to be protective against various stress. CO at a low concentration has been shown to be protective in several disease models mimicking the action of HO-1. We suggest that CO, the byproduct of heme degradation, could be valuable therapeutic agents. We review the functional role of HO-1 and CO and its potential application to clinical settings.
AB - Heme oxygenase (HO) catabolizes heme into three products: carbon monoxide (CO), biliverdin and free iron. HO-1, inducible form of HO, has been shown to be protective against various stress. CO at a low concentration has been shown to be protective in several disease models mimicking the action of HO-1. We suggest that CO, the byproduct of heme degradation, could be valuable therapeutic agents. We review the functional role of HO-1 and CO and its potential application to clinical settings.
UR - http://www.scopus.com/inward/record.url?scp=2542442816&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2542442816&partnerID=8YFLogxK
M3 - Review article
C2 - 15112495
AN - SCOPUS:2542442816
VL - 105
SP - 309
EP - 313
JO - Nihon Geka Gakkai zasshi
JF - Nihon Geka Gakkai zasshi
SN - 0301-4894
IS - 4
ER -