Abstract
Heme oxygenase (HO) catabolizes heme into three products: carbon monoxide (CO), biliverdin and free iron. HO-1, inducible form of HO, has been shown to be protective against various stress. CO at a low concentration has been shown to be protective in several disease models mimicking the action of HO-1. We suggest that CO, the byproduct of heme degradation, could be valuable therapeutic agents. We review the functional role of HO-1 and CO and its potential application to clinical settings.
| Original language | English |
|---|---|
| Pages (from-to) | 309-313 |
| Number of pages | 5 |
| Journal | Nippon Geka Gakkai zasshi |
| Volume | 105 |
| Issue number | 4 |
| Publication status | Published - Apr 2004 |
| Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)