Protective effect of carbon monoxide for organ injury

Atsunori Nakao, Eiji Kobayashi, Noriaki Tanaka, Noriko Murase

Research output: Contribution to journalReview article

Abstract

Heme oxygenase (HO) catabolizes heme into three products: carbon monoxide (CO), biliverdin and free iron. HO-1, inducible form of HO, has been shown to be protective against various stress. CO at a low concentration has been shown to be protective in several disease models mimicking the action of HO-1. We suggest that CO, the byproduct of heme degradation, could be valuable therapeutic agents. We review the functional role of HO-1 and CO and its potential application to clinical settings.

Original languageEnglish
Pages (from-to)309-313
Number of pages5
JournalNippon Geka Gakkai zasshi
Volume105
Issue number4
Publication statusPublished - 2004
Externally publishedYes

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Carbon Monoxide
Heme Oxygenase-1
Heme Oxygenase (Decyclizing)
Wounds and Injuries
Heme
Biliverdine
Iron
Therapeutics

Cite this

Nakao, A., Kobayashi, E., Tanaka, N., & Murase, N. (2004). Protective effect of carbon monoxide for organ injury. Nippon Geka Gakkai zasshi, 105(4), 309-313.

Protective effect of carbon monoxide for organ injury. / Nakao, Atsunori; Kobayashi, Eiji; Tanaka, Noriaki; Murase, Noriko.

In: Nippon Geka Gakkai zasshi, Vol. 105, No. 4, 2004, p. 309-313.

Research output: Contribution to journalReview article

Nakao, A, Kobayashi, E, Tanaka, N & Murase, N 2004, 'Protective effect of carbon monoxide for organ injury', Nippon Geka Gakkai zasshi, vol. 105, no. 4, pp. 309-313.
Nakao A, Kobayashi E, Tanaka N, Murase N. Protective effect of carbon monoxide for organ injury. Nippon Geka Gakkai zasshi. 2004;105(4):309-313.
Nakao, Atsunori ; Kobayashi, Eiji ; Tanaka, Noriaki ; Murase, Noriko. / Protective effect of carbon monoxide for organ injury. In: Nippon Geka Gakkai zasshi. 2004 ; Vol. 105, No. 4. pp. 309-313.
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