Protective effect of carbon monoxide for organ injury

Atsunori Nakao; Eiji Kobayashi; Noriaki Tanaka; Noriko Murase

Protective effect of carbon monoxide for organ injury

Atsunori Nakao, Eiji Kobayashi, Noriaki Tanaka, Noriko Murase

Research output: Contribution to journal › Review article › peer-review

Abstract

Heme oxygenase (HO) catabolizes heme into three products: carbon monoxide (CO), biliverdin and free iron. HO-1, inducible form of HO, has been shown to be protective against various stress. CO at a low concentration has been shown to be protective in several disease models mimicking the action of HO-1. We suggest that CO, the byproduct of heme degradation, could be valuable therapeutic agents. We review the functional role of HO-1 and CO and its potential application to clinical settings.

Original language	English
Pages (from-to)	309-313
Number of pages	5
Journal	Nippon Geka Gakkai zasshi
Volume	105
Issue number	4
Publication status	Published - Apr 2004
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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AU - Nakao, Atsunori

AU - Kobayashi, Eiji

AU - Tanaka, Noriaki

AU - Murase, Noriko

PY - 2004/4

Y1 - 2004/4

N2 - Heme oxygenase (HO) catabolizes heme into three products: carbon monoxide (CO), biliverdin and free iron. HO-1, inducible form of HO, has been shown to be protective against various stress. CO at a low concentration has been shown to be protective in several disease models mimicking the action of HO-1. We suggest that CO, the byproduct of heme degradation, could be valuable therapeutic agents. We review the functional role of HO-1 and CO and its potential application to clinical settings.

AB - Heme oxygenase (HO) catabolizes heme into three products: carbon monoxide (CO), biliverdin and free iron. HO-1, inducible form of HO, has been shown to be protective against various stress. CO at a low concentration has been shown to be protective in several disease models mimicking the action of HO-1. We suggest that CO, the byproduct of heme degradation, could be valuable therapeutic agents. We review the functional role of HO-1 and CO and its potential application to clinical settings.

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AN - SCOPUS:2542442816

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JO - Nihon Geka Gakkai zasshi

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SN - 0301-4894

IS - 4

ER -

Protective effect of carbon monoxide for organ injury

Abstract

ASJC Scopus subject areas

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