Protective effect of bifemelane hydrochloride on ischemic hippocampal CA1 neuronal damage in the Gerbil: Relation to induction of HSP70

X. H. Liu, K. Abe, M. Aoki, T. H. Lee, H. Kato, K. Kogure

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A protective effect of bifemelane hydrochloride (BF) on hippocampal CA1 neuronal death in gerbils was investigated following transient forebrain ischemia in relation to the induction of 70-kd heat shock protein (HSP70) and its mRNA. Histological examination showed that the neuronal density of the hippocampal CA1 sector treated with 10 and 30 mg/kg of BF (i.p.) was higher than that of the vehicle (p<0.05 and p<0.01, respectively) at 7 days after ischemia. Immunohistochemistry against HSP70 protein and in situ hybridization for the mRNA revealed that the inductions of immunoreactive HSP70 and the mRNA were remarkably reduced and limited in the brain hippocampi treated with BF (30 mg/kg) as compared with vehicle-treated animals. These data indicate that BF possesses a protective effect against ischemic injury to the vulnerable CA1 neurons. The possible mechanisms of the protection are discussed.

Original languageEnglish
Pages (from-to)161-167
Number of pages7
JournalLife Sciences
Volume53
Issue number2
DOIs
Publication statusPublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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