Protective effect of bifemelane hydrochloride on ischemic hippocampal CA1 neuronal damage in the Gerbil

Relation to induction of HSP70

X. H. Liu, Koji Abe, M. Aoki, T. H. Lee, H. Kato, K. Kogure

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A protective effect of bifemelane hydrochloride (BF) on hippocampal CA1 neuronal death in gerbils was investigated following transient forebrain ischemia in relation to the induction of 70-kd heat shock protein (HSP70) and its mRNA. Histological examination showed that the neuronal density of the hippocampal CA1 sector treated with 10 and 30 mg/kg of BF (i.p.) was higher than that of the vehicle (p

Original languageEnglish
Pages (from-to)161-167
Number of pages7
JournalLife Sciences
Volume53
Issue number2
DOIs
Publication statusPublished - 1993
Externally publishedYes

Fingerprint

HSP70 Heat-Shock Proteins
Gerbillinae
Hippocampal CA1 Region
Prosencephalon
Ischemia
Messenger RNA
bifemelane

ASJC Scopus subject areas

  • Pharmacology

Cite this

Protective effect of bifemelane hydrochloride on ischemic hippocampal CA1 neuronal damage in the Gerbil : Relation to induction of HSP70. / Liu, X. H.; Abe, Koji; Aoki, M.; Lee, T. H.; Kato, H.; Kogure, K.

In: Life Sciences, Vol. 53, No. 2, 1993, p. 161-167.

Research output: Contribution to journalArticle

@article{3c9ff2b16fdd4d7696f4cc99e889cdba,
title = "Protective effect of bifemelane hydrochloride on ischemic hippocampal CA1 neuronal damage in the Gerbil: Relation to induction of HSP70",
abstract = "A protective effect of bifemelane hydrochloride (BF) on hippocampal CA1 neuronal death in gerbils was investigated following transient forebrain ischemia in relation to the induction of 70-kd heat shock protein (HSP70) and its mRNA. Histological examination showed that the neuronal density of the hippocampal CA1 sector treated with 10 and 30 mg/kg of BF (i.p.) was higher than that of the vehicle (p",
author = "Liu, {X. H.} and Koji Abe and M. Aoki and Lee, {T. H.} and H. Kato and K. Kogure",
year = "1993",
doi = "10.1016/0024-3205(93)90663-N",
language = "English",
volume = "53",
pages = "161--167",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Protective effect of bifemelane hydrochloride on ischemic hippocampal CA1 neuronal damage in the Gerbil

T2 - Relation to induction of HSP70

AU - Liu, X. H.

AU - Abe, Koji

AU - Aoki, M.

AU - Lee, T. H.

AU - Kato, H.

AU - Kogure, K.

PY - 1993

Y1 - 1993

N2 - A protective effect of bifemelane hydrochloride (BF) on hippocampal CA1 neuronal death in gerbils was investigated following transient forebrain ischemia in relation to the induction of 70-kd heat shock protein (HSP70) and its mRNA. Histological examination showed that the neuronal density of the hippocampal CA1 sector treated with 10 and 30 mg/kg of BF (i.p.) was higher than that of the vehicle (p

AB - A protective effect of bifemelane hydrochloride (BF) on hippocampal CA1 neuronal death in gerbils was investigated following transient forebrain ischemia in relation to the induction of 70-kd heat shock protein (HSP70) and its mRNA. Histological examination showed that the neuronal density of the hippocampal CA1 sector treated with 10 and 30 mg/kg of BF (i.p.) was higher than that of the vehicle (p

UR - http://www.scopus.com/inward/record.url?scp=0027214952&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027214952&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(93)90663-N

DO - 10.1016/0024-3205(93)90663-N

M3 - Article

VL - 53

SP - 161

EP - 167

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 2

ER -