Protective effect of a novel free radical scavenger, OPC-14117, on wobbler mouse motor neuron disease

Koji Abe, S. Morita, T. Kikuchi, Y. Itoyama

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

A possible protective effect of a novel free radical scavenger, OPC- 14117, on the progressive motor neuron death in wobbler mice was examined. Clinical parameters such as mortality, body weight, motor activity as a rolling number of circular cage, and forelimb muscle power as grasping on a rolling column, an angle of slipping down from slope, and hanging ability on a flat plate were compared every 4 weeks from 4 to 36 weeks of age among mice groups treated with vehicle or daily oral administration of OPC-14117 of 10 or 30 mg/kg body weight. The treatment with OPC-14117 dose dependently improved the clinical parameters such as mortality, motor activity, and forelimb weakness. Pathological analysis showed that a diffuse neurogenic change in the forelimb muscle was improved at 36 weeks of age in the drug treated mice with a marked preservation of motor neurons in the spinal cord. Treatment of the mice with the drug reduced age-dependent increase of lipid peroxides in the spinal cord in vivo, and a supplement of the drug to the homogenate of spinal cord in vitro ameliorated the formations of lipid peroxides generated by an exogenous addition of ascorbate or xanthine/xanthine oxidase. These results suggest that OPC-14117 has a protective effect on the motor neuron death probably as a free radical scavenger, resulting in an improvement of clinical symptoms in wobber mice.

Original languageEnglish
Pages (from-to)63-70
Number of pages8
JournalJournal of Neuroscience Research
Volume48
Issue number1
DOIs
Publication statusPublished - Apr 1 1997
Externally publishedYes

Fingerprint

Motor Neuron Disease
Free Radical Scavengers
Forelimb
Motor Neurons
Spinal Cord
Lipid Peroxides
Motor Activity
Body Weight
Pharmaceutical Preparations
Muscles
Aptitude
Xanthine
Mortality
Xanthine Oxidase
Oral Administration
OPC 14117
Therapeutics

Keywords

  • free radical
  • motor neuron death
  • OPC-14117
  • wobbler mice

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Protective effect of a novel free radical scavenger, OPC-14117, on wobbler mouse motor neuron disease. / Abe, Koji; Morita, S.; Kikuchi, T.; Itoyama, Y.

In: Journal of Neuroscience Research, Vol. 48, No. 1, 01.04.1997, p. 63-70.

Research output: Contribution to journalArticle

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