Protection Against Ischemic Brain Damage in Rats by Immunophilin Ligand GPI-1046

Feng Li, Nobuhiko Omori, Takeshi Hayashi, Guang Jin, Keiko Sato, Isao Nagano, Mikio Shoji, Koji Abe

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

To determine the effect of immunophilin ligand GPI-1046 on ischemic brain injury, 90 min of transient middle cerebral artery occlusion (MCAO) was carried out in rat brains. In contrast to cases treated with vehicle, the infarct volume was reduced greatly and rotamase activity was inhibited significantly at 24 hr of reperfusion by treatment with GPI-1046. Immunoreactivity and the number of cells stained positively for FKBP12, FKBP52, caspase-8, cytochrome c, and caspase-3 were also reduced markedly in the brain after GPI-1046 treatment. The present results suggest that GPI-1046 significantly decreased infarct volume and provided neuroprotective effect on rats after transient focal cerebral ischemia by inhibiting the increase of rotamase activity and of the number of FKBP12-, FKBP52-, caspase-8-, cytochrome c-, and caspase-3-positive cells in the ischemic area.

Original languageEnglish
Pages (from-to)383-389
Number of pages7
JournalJournal of Neuroscience Research
Volume76
Issue number3
DOIs
Publication statusPublished - May 1 2004

Keywords

  • Caspase
  • FKBPs
  • GPI-1046
  • Rotamase

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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