Proteases produced by vibrios

Sumio Shinoda, Shin-ichi Miyoshi

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Bacteria of the genus Vibrio are normal habitants of the aquatic environment but the some species are believed to be human pathogens. Pathogenic vibrios produce various pathogenic factors, and the proteases are also recognized to play pathogenic roles in the infection: the direct roles by digesting many kinds of host proteins or indirect roles by processing other pathogenic protein factors. Especially VVP from Vibrio vulnificus is thought to be a major pathogenic factor of the vibrio. Although HA/P, the V. cholerae hemagglutinin/protease, is not a direct toxic factor of cholera vibrio, its significance is an undeniable fact. Production of HA/P is regulated together with major pathogenic factors such as CT (cholera toxin) or TCP (toxin co-regulated pilus) by a quorum-sensing system. HA/P is necessary for full expression of pathogenicity of the vibrio by supporting growth and translocation in the digestive tract. Processing of protein toxins such as CT or EI Tor hemolysin is also an important pathogenic role.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalBiocontrol Science
Volume16
Issue number1
DOIs
Publication statusPublished - Mar 10 2011

Fingerprint

Vibrio
Peptide Hydrolases
Cholera Toxin
Vibrio vulnificus
Quorum Sensing
Proteins
Hemolysin Proteins
Vibrio cholerae
Cholera
Poisons
Virulence
Gastrointestinal Tract
Bacteria
Growth
Infection

Keywords

  • Metalloprotease
  • Protease
  • Vibrio

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Public Health, Environmental and Occupational Health

Cite this

Proteases produced by vibrios. / Shinoda, Sumio; Miyoshi, Shin-ichi.

In: Biocontrol Science, Vol. 16, No. 1, 10.03.2011, p. 1-11.

Research output: Contribution to journalArticle

Shinoda, Sumio ; Miyoshi, Shin-ichi. / Proteases produced by vibrios. In: Biocontrol Science. 2011 ; Vol. 16, No. 1. pp. 1-11.
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