Prostate cancer gene therapy: Outcome of basic research and clinical trials

Y. Nasu, B. Djavan, M. Marberger, H. Kumon

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)

Abstract

With the advances in genetic engineering, tumor biology, and immunology, gene therapy has been recognized as a promising new treatment option for cancer, including prostate cancer. Several clinical trials of prostate cancer gene therapy currently underway are using therapeutic genes, including suicide genes, immunomodulatory genes, tumor suppressor genes, and antioncogenes. Although gene therapy for prostate cancer as a clinical alternative is still at an early stage that requires several technological breakthroughs, information obtained from clinical trials indicates the full potential of prostate cancer gene therapy. Concordant progress in basic research and gene therapy technology will ready prostate cancer gene therapy for widescale use in the future. In this report, the general concept and current progress in prostate cancer gene therapy are summarized.

Original languageEnglish
Pages (from-to)185-190
Number of pages6
JournalTechniques in Urology
Volume5
Issue number4
Publication statusPublished - Dec 16 1999

Keywords

  • Gene therapy
  • Genes
  • Outcome
  • Prostate cancer

ASJC Scopus subject areas

  • Urology

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