Prostaglandin E2 downregulates TNF-α-induced production of matrix metalloproteinase-1 in HCS-2/8 chondrocytes by inhibiting Raf-1/MEK/ERK cascade through EP4 prostanoid receptor activation

Kazunari Fushimi, Shigeru Nakashima, Fukka You, Masaham Takigawa, Katsuji Shimizu

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Medicine & Life Sciences

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