Prostaglandin E1-initiated immune regulation during human mixed lymphocyte reaction

Hideo K. Takahashi, Dong Xue, Hiromi Iwagaki, Ryuji Tamura, Goutarou Katsuno, Takahito Yagi, Tadashi Yoshino, Shuji Mori, Masahiro Nishibori, Noriaki Tanaka

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8 Citations (Scopus)

Abstract

Prostaglandin E1 (PGE1) has therapeutic value for transplantations due to its microvascular activity. Interleukin (IL)-18, which is elevated in plasma during the acute rejection after organ transplantation, elicits the expression of intercellular adhesion molecule (ICAM)-1, B7.1, B7.2, CD40, and CD40 ligand (CD40L) on monocytes as well as the production of interferon (IFN)-γ and IL-12 and proliferation of T-cells during the human mixed lymphocyte reaction (MLR) in an in vitro model of acute rejection. In contrast, PGE1 inhibits all the adhesion molecule expression, cytokine production and T-cell proliferation in the presence of IL-18. The effects of PGE1 depend on stimulation of the IP/EP2/EP4-receptor, and thus, PGE1 might have therapeutic potential for treating acute rejection due to its immune regulatory effect.

Original languageEnglish
Pages (from-to)85-92
Number of pages8
JournalClinical Immunology
Volume115
Issue number1 SPEC. ISS.
DOIs
Publication statusPublished - Apr 2005

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Keywords

  • Adhesion molecule
  • Human
  • IL-18
  • MLR
  • Prostaglandin

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Takahashi, H. K., Xue, D., Iwagaki, H., Tamura, R., Katsuno, G., Yagi, T., Yoshino, T., Mori, S., Nishibori, M., & Tanaka, N. (2005). Prostaglandin E1-initiated immune regulation during human mixed lymphocyte reaction. Clinical Immunology, 115(1 SPEC. ISS.), 85-92. https://doi.org/10.1016/j.clim.2004.12.001